GAS6蛋白是一種膠原結(jié)構(gòu)域含有的細(xì)胞因子，作為一種主要的生長調(diào)節(jié)因子，在調(diào)節(jié)細(xì)胞的增殖、分化和凋亡方面發(fā)揮重要作用。最新研究表明，GAS6蛋白參與了心血管疾病、惡性腫瘤等多種疾病的發(fā)生和發(fā)展。例如，在心肌梗死中，GAS6蛋白能夠保護心肌細(xì)胞免受凋亡的影響；在某些癌癥中，GAS6蛋白的高表達(dá)會促進癌細(xì)胞的增殖和遷移。

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.

1. Disinhibiation of Gas6 binding to Tyro3 due to PGRN reduction results in activation of PKCalpha via PLCgamma, inducing tau phosphorylation at Ser203, mislocalization of tau to dendritic spines, and spine loss. PMID: 29382817
2. Here, the mechanism by which norepinephrine (NE)regulates prostate cancer DTCs in the marrow is explored. NE directly stimulated prostate cancer cell proliferation through beta2-adrenergic receptors (ADRB2).. NE also altered prostate cancer proliferation in the marrow niche by indirectly downregulating the secretion of the dormancy inducing molecule growth arrest specific-6 (GAS6) expressed by osteoblasts. PMID: 28814453
3. This study demonstrated that the Gas6(-/-) Axl(-/-) double knockout (DKO) mice showed axonal damage, motor deficits, prolonged neuroinflammation, and less remyelination following cuprizone exposure. PMID: 28925029
4. Taken together, in our study Gas6 fails to aggravate calcification against the previous assumption. PMID: 27230889
5. The present study provides evidence that the vitamin K-dependent protein growth arrest specific 6 (Gas6) promotes such repair in in vitro cultures of mouse optic nerve and cerebellum. PMID: 27630207
6. Gas6/Axl and Akt/FoxO1a were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis. PMID: 27206970
7. Gas6-mediated uptake is not a means to clear the bulk of circulating membrane-derived microparticles (PMPs) but may serve to locally phagocytose PMPs generated at sites of platelet activation and as a way to effect endothelial responses. PMID: 27006397
8. Gas6-FoxO-1 signaling axis plays an important role in VCAM-1 expression in the context of venous thromboembolism by promoting bone marrow mononuclear cell-endothelial cell adhesion. PMID: 26414399
9. Gas6 and Axl serum levels increase in parallel to chronic liver disease progression inactivation. PMID: 25908269
10. Gas6, through upregulation of Ptges/PGE2, contributes to cancer-induced venous thrombosis. PMID: 26585956
11. Gas6-induced Axl signaling is a critical driver of pancreatic cancer progression. PMID: 26206560
12. Gas6/Axl signaling is essential for delaying the cellular senescence process regulated by the PI3K/Akt/FoxO signaling pathway. PMID: 25766527
13. The up-regulation of Gas6/Axl signaling is a protective mechanism which reduces tubulo-interstitial apoptosis and slows progression to end-stage renal failure. PMID: 25019319
14. Optimal TAM signaling requires coincident TAM ligand engagement of both its receptor and the phospholipid phosphatidylserine regulating TAM receptor tyrosine kinases Tyro3, Axl, and Mer and their ligands Gas6 and Protein S. PMID: 25265470
15. Inhibition of the Gas6 receptor Mer or therapeutic targeting of Gas6 by warfarin reduced myeloma burden and improved survival in a systemic model of myeloma. PMID: 25102945
16. data are consistent with Growth arrest-specific protein 6 being neuroprotective during experimental autoimmune encephalomyelitis by dampening the inflammatory response, thereby preserving axonal integrity and myelination. PMID: 25471571
17. These results demonstrate that Gas6 enhances several features of fungal allergic airway disease. PMID: 24810144
18. The expression of TAM receptor tyrosine kinases and their ligand Gas6 is markedly downregulated in psoriatic epidermis. These data are in concordance with earlier study, demonstrating that TAM-deficient mice develop systemic autoimmunity. PMID: 23684948
19. Gas6 deficiency enhanced mouse colitis-associated tumorigenesis. PMID: 23430954
20. Results demonstrate that Gas6 is a Mer ligand, and is active in Mer-driven phagocytosis in the retina. PMID: 23259948
21. Alpha-lipoic acid attenuates vascular calcification by inhibiting vascular smooth muscle apoptosis through two distinct mechanisms; preservation of mitochondrial function via its antioxidant potential and restoration of the Gas6/Axl/Akt survival pathway. PMID: 21362131
22. A self-regulatory mechanism of Toll-like receptor signalling through the suppression of Gas6 and ProS expression is described. PMID: 22043818
23. results strongly suggest that 1) the Gas6 signaling itself is important to the cytoplasmic maturation, but not nuclear maturation. PMID: 21850267
24. Study highlights the deleterious effect of Gas6 in the progression of steatosis to steatohepatitis and fibrosis. PMID: 21350191
25. GAS6 enhances repair following cuprizone-induced demyelination PMID: 21203420
26. These findings establish Gas6 as an important regulator of both central nervous system demyelination and remyelination. PMID: 21423702
27. Gas6 and Tyro3, Axl and Mer (TAM) receptors have roles in human and murine platelet activation and thrombus stabilization PMID: 20546121
28. Gas6 expression in macrophages was blocked by lipopolysaccharides (LPS), which also contributes to the inhibition of macrophage phagocytosis by LPS. PMID: 21039473
29. The Gas6 pathway might be a potential nonimmunosuppressive target to minimize hepatic graft-versus-host disease in patients receiving allogeneic hematopoietic stem cell transplantation. PMID: 20139094
30. IGF-I appears to be the primary proliferative signal in growth plate chondrocytes, whereas multiple factors including SCF, BDNF, and Gas6 regulate the pace of differentiation at the growth plate PMID: 19897599
31. Gas6 induces glomerular cell proliferation in NTN and contributes to glomerular injury and the progression of chronic nephritis. PMID: 12122116
32. Growth arrest-specific gene 6 is involved in glomerular hypertrophy in the early stage of diabetic nephropathy PMID: 12644472
33. Gas6-Axl pathway in vascular smooth muscle cells is activated by hydrogen peroxide PMID: 15123721
34. Data suggest that Gas6 is a unique growth factor for fibroblasts and post-translational gamma-carboxylation is necessary for its biological activity. PMID: 15184064
35. Gas-6 enhances the accumulation of adipose tissue in diet-induced obese mice PMID: 15731491
36. Akt/mTOR pathway is a key signaling cascade in Gas6-mediated mesangial and glomerular hypertrophy and there is a crucial role of Gas6/Axl and the Akt/mTOR pathway in the development of diabetic nephropathy PMID: 16014032
37. These results suggested that GAS6 is an estrogen target gene in mammary epithelial cells. PMID: 17174935
38. Gas6 signaling activated the phosphorylation of ERK1/2, SAPK/JNK, and Akt, but not p38 MAPK. These results suggest that Gas6 negatively regulates chondrogenic differentiation, at least through the MAPK pathway. PMID: 17459335
39. Gas6 amplifies endothelial cell (EC) activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation. PMID: 18156494
40. These observations provide insight into the mechanism by which Gas6 is downregulated during mesenchymal stem cells differentiation into chondrocytes. PMID: 18457663
41. The expression profiles of Axl, Mer, and Gas6 mRNA were increased in the corpus callosum in a temporal profile correlating with the increased migration and proliferation of microglia/macrophages in this model. PMID: 18480276
42. These findings identify a role for Gas6 in plaque composition and stability. PMID: 18570189
43. AChE was observed to dock with Gas6, the ligand for Mer, as well as with apolipoprotein E3 (but not apolipoprotein E4), both at the same site as the laminin interaction PMID: 18785927
44. Growth arrest-specific protein 6 deficiency impairs liver tissue repair after acute toxic hepatitis in mice. PMID: 19443073
45. the expression pattern of Mer on macrophage subpopulations in the spleen and its Gas6-dependent role in macrophage phagocytosis suggest an important role for Mer in the modulation of immune responses. PMID: 19631584

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Secreted.

KEGG: mmu:14456

STRING: 10090.ENSMUSP00000033828

UniGene: Mm.3982