Mouse anti-double stranded DNA antibody(IgM)ELISA Kit

Mouse anti-double stranded DNA antibody(IgM)ELISA Kit

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文獻引用 (14) 說明書下載

中文名稱：

小鼠抗雙鏈DNA抗體/天然DNA抗體(IgM)酶聯免疫試劑盒
貨號：

CSB-E12911m
規格：

96T/48T
價格：

￥3200/￥2500
其他：

CUSABIO Wins 2024 Bioz Rapid Star? Award in the ELISA category

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產品描述：

小鼠抗雙鏈DNA抗體/天然DNA抗體(IgM)酶聯免疫試劑盒（CSB-E12911m）為捕獲法ELISA試劑盒，定量檢測血清、血漿樣本中的dsDNA Ab (IgM)含量。dsDNA Ab (IgM) 即抗雙鏈DNA抗體（IgM類）。在系統性紅斑狼瘡等自身免疫病中，機體免疫系統失調產生該抗體，它可與體內雙鏈DNA結合形成免疫復合物，沉積在組織器官引發炎癥損傷。深入研究其作用機制，對疾病診斷和治療有重要意義。試劑盒檢測范圍為1.56 ng/mL-100 ng/mL，該產品可廣泛應用于自身免疫疾病機制研究、藥物開發中抗體水平動態監測、免疫調控實驗評估等科研場景，為動物模型中的免疫應答分析及病理機制探索提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
縮寫：

dsDNA Ab (IgM)
種屬：

Mus musculus (Mouse)
樣本類型：

serum, plasma
檢測范圍：

1.56 ng/mL-100 ng/mL
靈敏度：

0.39 ng/mL
反應時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領域：

Others
測定原理：

quantitative
測定方法：

Capture ELISA

精密度：

線性度：

To assess the linearity of the assay, samples were spiked with high concentrations of mouse anti-double stranded DNA antibody (IgM) (dsDNA Ab (IgM)) in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
	Sample	Serum(n=4)
1:1	Average %	95
	Range %	85-105
1:2	Average %	89
	Range %	85-98
1:4	Average %	93
	Range %	85-97
1:8	Average %	95
	Range %	89-110

回收率：

The recovery of mouse anti-double stranded DNA antibody (IgM) (dsDNA Ab (IgM)) spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type	Average % Recovery	Range
Serum (n=5)	94	83-101
EDTA plasma (n=4)	97	87-106

標準曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ng/ml	OD1	OD2	Average	Corrected
100	2.501	2.531	2.516	2.377
50	2.178	2.203	2.191	2.052
25	1.803	1.822	1.813	1.674
12.5	1.254	1.268	1.261	1.122
6.25	0.731	0.745	0.738	0.599
3.12	0.405	0.397	0.401	0.262
1.56	0.255	0.249	0.252	0.113
0	0.138	0.140	0.139

數據處理：

ELISA操作視頻及標曲繪制軟件下載
貨期：

3-5 working days

Therapeutic Potential of Lipid Nanoparticle‐Encapsulated CD19‐Targeting mRNAs in Lupus and Rheumatoid Arthritis C Guo, Y Tang, L Zeng, X You, S Luo, Y Du,Advanced Science,2025
Dioscin attenuates lupus nephritis in NZB/W F1 mice by decreasing NF-κB activation and NLRP3 inflammasome Y Xu,Folia histochemica et cytobiologica,2024
Lipopolysaccharide released from gut activates pyroptosis of macrophages via Caspase 11‐Gasdermin D pathway in systemic lupus erythematosus Y Xin,MedComm,2024
Reciprocal regulation of SIRT1 and AMPK by Ginsenoside compound K impedes the conversion from plasma cells to mitigate for podocyte injury in MRL/lpr mice in a B cell-specific manner Z Song,Journal of ginseng research,2024
IL-38, a potential therapeutic agent for lupus, inhibits lupus progression WD Xu,Inflammation research,2023
YY1 alleviates lupus nephritis-induced renal injury by reducing the Th17/Treg cell ratio via the IFN-γ/Fra2 axis B Wang,Laboratory investigation,2023
Fasudil Compensates Podocyte Injure Via CaMK4/Rho GTpases Signal And Actin Cytoskeleton-Dependent Activation of YAP in MRL/lpr Mice F Tian,SSRN,2023
Jieduquyuziyin prescription promotes the efficacy of prednisone via upregulating Nrf2 in MRL/lpr kidneys L Du,Journal of ethnopharmacology,2022
Inhibition of GSK‐3β/HIF‐1α pathway alleviates NLRP3‐mediated pyroptosis induced by high glucose in renal tubular epithelial cells J Wan,Experimental physiology,2022
A Tissue-Tended Mycophenolate-Modified Nanoparticle Alleviates Systemic Lupus Erythematosus in MRL/Lpr Mouse Model Mainly by Promoting Local M2-Like Macrophagocytes Polarization B Jiang,International journal of nanomedicine,2022
A Tissue-Tended Mycophenolate-Modified Nanoparticle Alleviates Systemi BT Tok,/,2022
Vasoactive intestinal peptide ameliorates renal injury in a pristane-induced lupus mouse model by modulating Th17/Treg balance Dongdong Fu, et al,Bmc Nephrology,2019
Apoptotic cell-mimicking gold nanocages loaded with LXR agonist for attenuating the progression of murine systemic lupus erythematosus Xu N, et al,Biomaterials,2019
RNAi Silencing of HIF-1α Ameliorates Lupus Development in MRL/lpr Mice Wei Zhao.et al,Inflammation,2018

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Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.