Mouse Interleukin-22 receptor subunit alpha-2(IL22RA2) ELISA kit

Mouse Interleukin-22 receptor subunit alpha-2(IL22RA2) ELISA kit

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中文名稱：

小鼠白介素-22受體α-2亞基(IL22RA2)酶聯免疫試劑盒
貨號：

CSB-EL011637MO
規格：

96T/48T
價格：

￥3600/￥2500
促銷：
其他：

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產品描述：

小鼠白介素-22受體α-2亞基(IL22RA2)酶聯免疫試劑盒（CSB-EL011637MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的IL22RA2含量。IL22RA2是一個靶點。它是白細胞介素 22 的受體亞基，在免疫調節等生理過程中可能發揮重要作用。相關研究或聚焦其與疾病發生發展關聯機制，如免疫失衡、炎癥反應等，探索以此為靶點開發治療藥物或干預手段。試劑盒檢測范圍為46.88 pg/mL-3000 pg/mL，可為科研人員探究IL22RA2在免疫調節機制、炎癥性疾病模型或腫瘤發生發展中的動態變化提供可靠工具；適用于基礎研究中對體液或組織樣本的蛋白表達水平監測，為探索相關疾病的分子機制提供數據支持。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
別名：

Il22ra2Interleukin-22 receptor subunit alpha-2 ELISA Kit; IL-22 receptor subunit alpha-2 ELISA Kit; IL-22R-alpha-2 ELISA Kit; IL-22RA2 ELISA Kit; Cytokine receptor family type 2 ELISA Kit; soluble 1 ELISA Kit; CRF2-S1 ELISA Kit; Interleukin-22-binding protein ELISA Kit; IL-22BP ELISA Kit; IL22BP ELISA Kit; ZcytoR16 ELISA Kit
縮寫：

IL22RA2
Uniprot No.：

Q80XF5
種屬：

Mus musculus (Mouse)
樣本類型：

serum, plasma, tissue homogenates
檢測范圍：

46.88 pg/mL-3000 pg/mL
靈敏度：

11.7 pg/mL
反應時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領域：

Immunology
測定原理：

quantitative
測定方法：

Sandwich

精密度：

線性度：

To assess the linearity of the assay, samples were spiked with high concentrations of mouse IL22RA2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
	Sample	Serum(n=4)
1:1	Average %	94
	Range %	90-97
1:2	Average %	100
	Range %	95-103
1:4	Average %	95
	Range %	89-100
1:8	Average %	89
	Range %	84-92

回收率：

The recovery of mouse IL22RA2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type	Average % Recovery	Range
Serum (n=5)	95	90-97
EDTA plasma (n=4)	95	91-98

標準曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

pg/ml	OD1	OD2	Average	Corrected
3000	2.412	2.423	2.418	2.258
1500	1.812	1.776	1.794	1.634
750	1.116	1.078	1.097	0.937
375	0.705	0.688	0.697	0.537
187.5	0.434	0.459	0.447	0.287
93.75	0.322	0.314	0.318	0.158
46.88	0.256	0.243	0.250	0.090
0	0.162	0.158	0.160

數據處理：

ELISA操作視頻及標曲繪制軟件下載
貨期：

3-5 working days

Delivery of interleukin-22 binding protein (IL-22BP) gene by cationic micelle for colon cancer gene therapy Ke Men.et al,The Royal Society of Chemistry,2018

功能：

Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
基因功能參考文獻：
1. limits the pathological manifestations in models of allergic contact dermatitis and psoriasis PMID: 27676439
2. Il22bp-deficient mice were more susceptible to acute liver damage in models of acute liver damage induced by ischemia reperfusion and acetaminophen administration. IL-22BP plays a protective role in acute liver damage, via controlling IL-22-induced Cxcl10 expression. PMID: 29109123
3. IL-22BP promotes bacterial uptake into Peyer's patches by influencing follicle-associated epithelium gene expression and function. PMID: 28512157
4. IL22RA2 KO displayed a less severe EAE course, less demyelination and less infiltration of immune cells in the CNS. PMID: 25008863
5. the IL-22-IL-22BP axis critically regulates intestinal tissue repair and tumorigenesis in the colon PMID: 23075849
6. cloning and characterization; gene encodes a protein of 230 amino acids that share 67.1% amino-acid sequence identity with human IL-22 binding protein; upregulated by LPS stimulation in monocytes PMID: 12700595
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亞細胞定位：

Secreted.
蛋白家族：

Type II cytokine receptor family
組織特異性：

Highly expressed in lymph nodes and at lower levels in lung, spleen, and thymus. Not expressed in kidney, liver and heart.
數據庫鏈接：

KEGG: mmu:237310

STRING: 10090.ENSMUSP00000042642

UniGene: Mm.331979

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.