Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.; Exhibits antimicrobial activity against Gram-negative bacterias, inducing bacterial membrane blebbing. Exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2.

1. this study demonstrates anti-obesity effect of intranasal administration of galanin-like peptide in obese mice PMID: 27323911
2. we investigated whether PI3K signalling in neurones expressing GALP plays a role in the transcriptional regulation of the GALP gene PMID: 24796383
3. results indicate the GALP ICV administration can further promote energy metabolism when administered to spontaneously exercising mice PMID: 24055807
4. Distinct expression of alarin, a splice variant of GALP, in the adult mouse brain demonstrates potential functions in reproduction and metabolism. PMID: 21647713
5. hypothalamic GALP gene expression is controlled by leptin signals PMID: 12746327
6. GALP may play a role in readjusting energy balance under changing nutritional circumstances PMID: 18775887

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Secreted.

Galanin family

Isoform 2 is found in brain, thymus and skin. Isoform 2 is found in the skin, in pericytes covering microvascular arterioles and venules on their abluminal surfaces. In larger vessels, isoform 2 is expressed in layers of smooth muscle cells. Isoform 2 is

KEGG: mmu:232836

STRING: 10090.ENSMUSP00000037408

UniGene: Mm.246599