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中文名稱：人Ⅰ型前膠原N端前肽(PⅠNP)酶聯免疫試劑盒
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貨號：CSB-E11226h
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規格：96T/48T
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價格：￥3200/￥2500
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其他：
產品詳情
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產品描述：人Ⅰ型前膠原N端前肽(PⅠNP)酶聯免疫試劑盒（CSB-E11226h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的PⅠNP含量。PⅠNP即I型前膠原氨基端前肽，它是反映成骨細胞活性和骨形成的特異性指標。其背景在于可用于評估骨代謝狀態。研究機制上，主要是通過檢測血液中PⅠNP水平，來反映骨合成代謝過程，輔助診斷和監測骨質疏松癥等骨病。試劑盒檢測范圍為18.75 pg/mL-1200 pg/mL，適用于骨組織工程研究、骨骼疾病動物模型評估、骨代謝相關分子機制解析等科研場景，為骨代謝研究、抗骨質疏松藥物篩選及骨再生材料開發提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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別名：procollagen 1 N-terminal peptide,P1NP,_x000D_ procollagen I N-terminal peptide,PINP
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縮寫：PⅠNP
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種屬：Homo sapiens (Human)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：18.75 pg/mL-1200 pg/mL
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靈敏度：4.68 pg/mL
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Others
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of human PⅠNP in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:100 Average % 97 Range % 89-102 1:200 Average % 90 Range % 83-97 1:400 Average % 99 Range % 94-105 1:800 Average % 96 Range % 90-102 -
回收率：
The recovery of human PⅠNP spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 94 90-99 EDTA plasma (n=4) 101 95-107 -
標準曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
pg/ml OD1 OD2 Average Corrected 1200 2.191 2.287 2.239 2.086 600 1.885 1.896 1.891 1.738 300 1.527 1.507 1.517 1.364 150 1.001 1.042 1.022 0.869 75 0.692 0.648 0.670 0.517 37.5 0.499 0.472 0.486 0.333 18.75 0.272 0.288 0.280 0.127 0 0.152 0.154 0.153 -
數據處理：
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貨期：3-5 working days
引用文獻
- Bone metabolism and inflammatory biomarkers in radiographic and non-radiographic axial spondyloarthritis patients: a comprehensive evaluation I Gómez-García,Frontiers in endocrinology,2024
- Changes in bone turnover markers in patients without bone metastases receiving immune checkpoint inhibitors: An exploratory analysis F Pantano,Journal of bone oncology,2022
- Praeruptorin B inhibits osteoclastogenesis by targeting GSTP1 and impacting on the S-glutathionylation of IKKβ K Xu,Biomedicine & pharmacotherapy,2022
- Three-Dimensional Co-Culture System of Human Osteoblasts and Osteoclast Precursors from Osteoporotic Patients as an Innovative Model to Study the Role of Nutrients: Focus on Vitamin K2 Domitilla Mandatori,Nutrients,2021
- Increasing Vegetable Intake Decreases Urinary Acidity and Bone Resorption Marker in Overweight and Obese Adults: An 8-Week Randomized Controlled Trial JJ Cao,The Journal of nutrition,2021
- TAZ inhibits osteoclastogenesis by attenuating TAK1/NF-κB signaling W Yang,Bone Research,2021
- Citrate Supplementation Restores the Impaired Mineralisation Resulting from the Acidic Microenvironment: An In Vitro Study N Swilam,Nutrients,2020
- Umbilical cord N-terminal procollagen of type l collagen (P1NP) and beta C-terminal telopeptide (βCTX) levels in term pregnancies with vitamin D deficiency M Eraslan Sahin,Journal Gynecological Endocrinology,2020
- Association between bile acid metabolism and bone mineral density in postmenopausal women Zhao YX,Clinics (Sao Paulo),2020
- Dissecting the mechanisms of bone loss in Gorham-Stout disease Michela Rossi, et al,Bone,2019
- Spine bone mineral density increases after 6 months of exclusive lactation, even in women who keep breastfeeding Cooke-Hubley S.et al,Arch Osteoporos,2017
- Physical activity and hypocaloric diet recovers osteoblasts homeostasis in women affected by abdominal obesity Viviana M.et al,Springer US,2016
- Effect of chronic activity-based therapy on bone mineral density and bone turnover in persons with spinal cord injury Astorino TA et al,Eur J Appl Physiol,2013
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