1. The rs34349826 and rs6521 loci of the LHB gene were not related to male infertility, which can be further confirmed by larger-sample studies. The GG genotype combination is a protective factor against male infertility. PMID: 30173455
2. Homozygous nonsense mutation Trp28X in the LHB gene causes LH deficiency. PMID: 29476300
3. A 20-year-old male from a consanguineous family had pubertal delay, hypogonadism and undetectable LH. A homozygous c.118_120del (p.Lys40del) mutation was identified in the patient and his brother, who subsequently had the same phenotype. PMID: 27656125
4. In girls with central precocious puberty, increased body mass index (BMI) was associated with slightly lower peak stimulated luteinizing hormone (LH) levels at early pubertal stages (Tanner stages 2 and 3). PMID: 27215137
5. LHbeta G1052A and LHCGR G935A genes polymorphisms are associated with increased risk of polycystic ovary syndrome in Egyptian women especially in obese cases. PMID: 26662070
6. The Trp8Arg/Ile15Thr polymorphism within the LHB gene was not associated with endometriosis and infertility. PMID: 25935136
7. This paper shows a conclusive contribution of Variant-Luteinizing hormone to the natural variance in male serum Luteinizing hormone levels PMID: 25820123
8. the frequency of v-betaLH in Denmark is similar to a number of European countries PMID: 23725475
9. LH, progesterone, and TSH can stimulate aldosterone. PMID: 24297486
10. Data indicate a modulatory effect of luteinizing hormone beta-subunit (LHB) gene polymorphisms on hyperandrogenemia phenotype of Polycystic Ovary Syndrome (PCOS) was observed. PMID: 25111116
11. No association was found between poor ovarian response to ovarian stimulation and variant-betaLH. PMID: 24625195
12. Both estradiol and progesterone uniquely modulate basal and GnRH-stimulated gonadotropin promoters without affecting cell growth. PMID: 23160221
13. FOXO1 transcription factor inhibits luteinizing hormone beta gene expression in pituitary gonadotrope cells PMID: 22865884
14. Results suggested LH G1052A mutation might influence polycystic ovary syndrome susceptibility and phenotypes. PMID: 22546001
15. Polymorphisms of Trp8Arg and Ile15Thr in the LH-beta subunit gene occur in infertile women. PMID: 22108961
16. We identified seven SNPs in the LH beta gene; one SNP in exon 3 (rs#1056917) exhibited significant difference in the allele frequency between the PCOS cases and controls PMID: 22209983
17. the presence of LHbeta G1502A and ERbeta G+1730A polymorphisms is associated with infertility and endometriosis associated infertility.When two polymorphisms are present it does not appear to increase the chance of developing endometriosis or infertility. PMID: 21764500
18. Both normal-weight and overweight women with classic PCOS phenotypes present higher LH levels and LH-to-FSH ratios than women with similar BMI but the newer phenotypes. PMID: 21353371
19. A dileucine determinant in the carboxyl terminal sequence of the luteinizing hormone beta subunit is implicated in the regulated secretion of lutropin PMID: 21458524
20. Variant LH remains longer in circulation than wild type during GnRH receptor blockade in heterozygous women, in accord with its higher content of sialic acid. PMID: 19890021
21. relationship between endometriosis and a variant of the beta-subunit of luteinizing hormone PMID: 12042273
22. findings demonstrate that Gly(102)Ser mutation of the LHbeta gene does not affect receptor binding and bioactivity of the hormone, when tested in vitro PMID: 12356936
23. Results suggest that a single nucleotide polymorphism alters the post-translational modification of luteinizing hormone beta and hence its structural phenotype. PMID: 12683946
24. MIP-2A (MBP-1 interacting protein-2A) preferentially expresses in certain tissues, including the pituitary gland, and negatively regulates the LHbeta gene transcription PMID: 12700240
25. genetically determined variation in LH function might affect susceptibility to prostate cancer via altered testosterone secretion. PMID: 12746844
26. pituitary exit of LH and FSH occur via different secretion pathways, and are released spatially from the pituitary via different circulatory routes. PMID: 14585810
27. LH modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition PMID: 14871891
28. LHbeta-null mice are viable but demonstrate postnatal defects in gonadal growth and function resulting in infertility. PMID: 15569941
29. The tight linkage between the two missense substitutions in the coding region and the eight nucleotide substitutions in the promoter region of LHB appears to be common to various ethnic groups. PMID: 16410673
30. homozygous mutation of a 5' splice site in LHB: IVS2+1G-->C disrupts the splicing of messenger RNA, generating a gross abnormality in the processing of the luteinizing hormone beta-subunit mRNA, which abrogates the secretion of luteinizing hormone PMID: 17761593
31. GnRH stimulation of signaling pathway for annexin A5 mRNA expression is distinct from that of LHbeta mRNA and dependent more on MAPK. PMID: 18703851
32. Progesterone feedback at the level of the pituitary gonadotrope is likely to play a key role in differential production of the gonadotropin genes. PMID: 19106225
33. Inactivating mutations of luteinizing hormone beta-subunit or luteinizing hormone receptor cause oligo-amenorrhea and infertility in women. PMID: 19129711
34. v-betaLH is more frequent in women with ovarian resistance to rhFSH. PMID: 19146763

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HGNC: 6584

OMIM: 152780

KEGG: hsa:3972

STRING: 9606.ENSP00000221421

UniGene: Hs.154704