1. Endogenous NTN4/NEO1 maintain neuroblastoma growth via both pro-survival and pro-migratory molecular signaling. PMID: 28038459
2. Data indicate that OR3A4 upregulation contributes to metastasis and tumorigenesis in gastric cancer by regulating the activation of PDLIM2, MACC1, NTN4, and GNB2L1. PMID: 26863570
3. NTN4 is reduced in breast cancer tissues and NTN4 is associated with breast cancer cell migration and invasion via regulation of epithelial mesenchymal transition (EMT)-related biomarkers. PMID: 27840993
4. We found statistically significant association with AAO for three genes (WRN, NTN4 and LAMC3) with common associated variants. PMID: 26394601
5. inhibits placental microvascular endothelial cells proliferation, tube-like formation, migration and spheroid sprouting PMID: 26390805
6. Ntn4 promotes the proliferation and motility of gastric cancer cells which is mediated by its receptor Neo and through further activation of multi-oncogenic pathways PMID: 25909166
7. Increased expression of miR-20a may play an important role in the pathogenesis of ovarian endometriosis by suppressing NTN4 expression. PMID: 24972566
8. Increased maternal netrin-4 levels in IUGR neonates may reflect in utero hypoxia, while the negative correlations between fetal netrin-1 and -4 levels may exert the dynamic balance between their angio- and anti-angiogenic properties. PMID: 24716747
9. NTN4 acts as a positive regulator for TC axon branching through activity-dependent expression PMID: 25288737
10. NETRIN-4 protects glioblastoma cells FROM temozolomide induced senescence. PMID: 24265816
11. NTN4 expression was downregulated in cervical cancer tissues compared to normal controls, and in vivo mRNA level of NTN4 inversely correlated with miR-196a expression. PMID: 24120501
12. pattern of distribution suggests that a functional netrin-4-neogenin pathway might be restricted to syncytiotrophoblasts, mesenchymal cells, and villous endothelial cells PMID: 22705235
13. glioma cells reduce netrin-4 expression to decrease its inhibitory effects. PMID: 22496621
14. Netrin-4 is upregulated in breast carcinoma effusions compared to corresponding solid tumors PMID: 20730893
15. The alpha6beta1 integrin is a netrin-4 receptor in endothelial cells. PMID: 21799154
16. NT-4 overexpression decreases tumor growth and carcinomatosis, probably via an antiangiogenic effect PMID: 21406174
17. Loss of NTN4 by methylation is associated with breast cancer. PMID: 19859801
18. Netrin-4, at physiologic doses, induces proliferation, migration, adhesion, tube formation and survival of human lymphatic endothelial cells. PMID: 20407033
19. NTN4, TRA1, and STC2 have roles in progression of breast cancer PMID: 17545519
20. Knockdown of Netrin-4 expression in EC increased their ability to form tubular structures; Netrin-4 bound only to neogenin but not to Unc5B or Unc5C receptors PMID: 18719102
21. A potential role for netrin-4 in regulating tumor growth. PMID: 19094984

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HGNC: 13658

OMIM: 610401

KEGG: hsa:59277

STRING: 9606.ENSP00000340998

UniGene: Hs.201034