1. Vag8 binding to human C1-inhibitor (C1-inh) interferes with the binding of C1-inh to C1s, C1r and MASP-2, resulting in the release of active proteases that subsequently cleave C2 and C4 away from the bacterial surface. PMID: 28742139
2. Solution Structures of Complement C2 and Its C4 Complexes Propose Pathway-specific Mechanisms for Control and Activation of the Complement Proconvertases. PMID: 27252379
3. The rs2844455 A allele of C2 is a risk factor for systemic lupus erythematosus development in a Chinese population, whereas the G allele might be a protective factor. PMID: 26176736
4. our data indicate that C2 rs547154 polymorphism plays a protective role in the development of PCV. PMID: 25732348
5. Inhibition of c3 convertase activity by hepatitis C virus as an additional lesion in the regulation of complement components. PMID: 24983375
6. These overall results suggest a lack of strong association with the C2 and C7 gene polymorphisms to the susceptibility of systemic lupus erythematosus in the Malaysian population. PMID: 21881993
7. Results showed that missense mutations in transmembrane protein 2 p.Ser1254Asn, interferon alpha 2 p.Ala120Thr, its regulator NLR family member X1 p.Arg707Cys, and complement component 2 p.Glu318Asp were associated with chronic hepatitis B. PMID: 22610944
8. CFH (RS1061170), C2 (RS547154), OR CFB (RS438999) was not associated with early or late AMD. PMID: 23060141
9. These data suggest that patients with C2 deficiency are at increased risk of Streptococcus pyogenes infections. PMID: 20417301
10. C2 microheterogeneity and histocompatibility antigens Class I were studied in an Austrian population. PMID: 12823772
11. study of the formation of high affinity C5 convertase of the classical pathway of complement PMID: 12878586
12. Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2 PMID: 16670774
13. a weaker, independent protective effect exists for complement component 2 in age related macular degeneration. PMID: 17576744
14. These data confirm that the classical pathway is vital for complement-mediated phagocytosis of S. pneumoniae and demonstrate why subjects with a C2 deficiency have a marked increase in susceptibility to S. pneumoniae infections. PMID: 18541650
15. Study provides insights into the genetic pathogenesis of AMD, and C2 has been shown as one of the five genes independently involved in progression from intermediate disease to advanced disease in which blindness is frequent. PMID: 19015224
16. Upon cleavage by C1s, C2a domains undergo conformational rotation while bound to C4b and the released C2b domains may remain folded together as seen in the intact protein. PMID: 19237749

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HGNC: 1248

OMIM: 217000

KEGG: hsa:717

STRING: 9606.ENSP00000299367

UniGene: Hs.408903