YAP1
YAP1，即yes相關(guān)蛋白1，別名Yes1 Associated Transcriptional Regulator、YAP652、YAP-12、Yes-Associated Protein YAP65 Homolog、Transcriptional Coactivator YAP1、Yes Associated Protein 123、Protein Yorkie Homolog、Yes-Associated Protein 1, 65kDa等 。它是一種轉(zhuǎn)錄共激活因子，其活性受Hippo信號通路控制，在正常組織穩(wěn)態(tài)和再生中發(fā)揮重要作用，也在癌癥發(fā)生、侵襲、轉(zhuǎn)移和治療抵抗中發(fā)揮著重要作用 。YAP1的作用機制主要是通過與Hippo信號通路中的激酶級聯(lián)反應相關(guān)，影響細胞增殖和凋亡。當Hippo信號通路激活時，YAP1會被LATS1/2激酶磷酸化，導致其在細胞質(zhì)中隔離和蛋白酶體降解。而當Hippo信號通路關(guān)閉時，YAP1去磷酸化并轉(zhuǎn)移到細胞核中，與轉(zhuǎn)錄因子如TEAD家族成員結(jié)合，激活下游基因的表達，從而調(diào)控細胞生長、代謝、增殖、遷移、侵襲或死亡 。此外，YAP1還參與調(diào)控組織張力和3D組織形態(tài)，通過調(diào)節(jié)皮層肌動蛋白網(wǎng)絡形成發(fā)揮作用 。YAP1在生物學上的意義非常廣泛，它不僅參與了組織生長和器官大小的調(diào)控，還與多種疾病的發(fā)生發(fā)展密切相關(guān)。YAP1的異常表達或功能失調(diào)與腫瘤的發(fā)生、侵襲性、轉(zhuǎn)移和治療抵抗性有關(guān)，是癌癥治療中的一個潛在靶點。此外，YAP1還參與了免疫應答、細胞接觸反應、細胞增殖和凋亡等重要生物學過程的調(diào)控 。
熱銷產(chǎn)品
Recombinant Human Transcriptional coactivator YAP1 (YAP1) (CSB-YP026244HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗證數(shù)據(jù)
Western Blot analysis of HepG2 cells using YAP Polyclonal Antibody
Western Blot analysis of HepG2 RAT-MUSCLE cells using YAP Polyclonal Antibody
YAP1 Antibodies
YAP1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA026244GA01HU | YAP1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA593016 | Phospho-YAP1 (Ser127) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA913770 | YAP1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000707 | Phospho-YAP1 (S127) Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
| CSB-PA004537 | YAP1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA004538 | YAP1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-RA026244A127phHU | Phospho-YAP1 (S127) Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
| CSB-PA026244LA01HU | YAP1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA026244LB01HU | YAP1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA026244LC01HU | YAP1 Antibody, FITC conjugated | Human | |
| CSB-PA026244LD01HU | YAP1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA026244LA11HU | YAP1 Antibody | Human | ELISA, WB, IF |
| CSB-PA026244LB11HU | YAP1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA026244LC11HU | YAP1 Antibody, FITC conjugated | Human | |
| CSB-PA026244LD11HU | YAP1 Antibody, Biotin conjugated | Human | ELISA |
YAP1 Proteins
YAP1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP026244HU | Recombinant Human Transcriptional coactivator YAP1 (YAP1) | Yeast |
| CSB-EP026244HU | Recombinant Human Transcriptional coactivator YAP1 (YAP1) | E.coli |
| CSB-BP026244HU CSB-MP026244HU CSB-EP026244HU-B |
Recombinant Human Transcriptional coactivator YAP1 (YAP1) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP026244HUc7 | Recombinant Human Transcriptional coactivator YAP1 (YAP1) | E.coli |
| CSB-EP026244HUd7 | Recombinant Human Transcriptional coactivator YAP1 (YAP1) | E.coli |
YAP1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP026244MO CSB-EP026244MO CSB-BP026244MO CSB-MP026244MO CSB-EP026244MO-B |
Recombinant Mouse Yorkie homolog (Yap1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
YAP1 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP026244CH CSB-EP026244CH CSB-BP026244CH CSB-MP026244CH CSB-EP026244CH-B |
Recombinant Chicken Yorkie homolog (YAP1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
YAP1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP323980SVG CSB-EP323980SVG CSB-BP323980SVG CSB-MP323980SVG CSB-EP323980SVG-B |
Recombinant Saccharomyces cerevisiae AP-1-like transcription factor YAP1 (YAP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
YAP1 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP345945KBK CSB-EP345945KBK CSB-BP345945KBK CSB-MP345945KBK CSB-EP345945KBK-B |
Recombinant Kluyveromyces lactis AP-1-like transcription factor (YAP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
YAP1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP645005RA CSB-EP645005RA CSB-BP645005RA CSB-MP645005RA CSB-EP645005RA-B |
Recombinant Rat Yorkie homolog (Yap1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
