WEE1
WEE1，全稱為Wee1-like protein kinase，也被稱為WEE1A，是一種參與細胞周期調控的重要蛋白激酶。它通過抑制細胞周期蛋白依賴性激酶1（CDK1）的活性，阻止細胞從G2期進入M期，從而確保DNA復制完成并得到修復。WEE1蛋白在多種生物中均有表達，包括人類、小鼠、大鼠等。
WEE1蛋白與多種疾病的發生發展密切相關。研究表明，WEE1蛋白在多種腫瘤中高表達，包括乳腺癌、卵巢癌、肺癌、黑色素瘤等。WEE1蛋白的高表達會導致細胞周期阻滯，從而抑制腫瘤細胞的增殖。因此，WEE1蛋白被認為是抗腫瘤治療的理想靶點。
目前，針對WEE1蛋白的小分子抑制劑已成為抗腫瘤藥物研發的熱點。例如，阿斯利康公司開發的Adavosertib（AZD1775）是首個進入臨床試驗的WEE1抑制劑，其在治療卵巢癌和漿液性子宮內膜癌方面取得了顯著療效。此外，還有其他多家制藥公司也在積極研發WEE1抑制劑，這些抑制劑有望成為治療腫瘤的新型藥物。
熱銷產品
Recombinant Human Wee1-like protein kinase (WEE1) (CSB-EP026084HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
WEE1 Antibodies
WEE1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA062918 | Phospho-WEE1 (Ser642) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA060083 | Phospho-WEE1 (S642) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA060084 | Phospho-WEE1 (S53) Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA060085 | WEE1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA16059A0Rb | WEE1 Antibody | Human | ELISA |
| CSB-PA16059B0Rb | WEE1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA16059C0Rb | WEE1 Antibody, FITC conjugated | Human | |
| CSB-PA16059D0Rb | WEE1 Antibody, Biotin conjugated | Human | ELISA |
WEE1 Proteins
WEE1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP026084HU CSB-BP026084HU CSB-MP026084HU CSB-EP026084HU-B |
Recombinant Human Wee1-like protein kinase (WEE1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP026084HU | Recombinant Human Wee1-like protein kinase (WEE1) | E.coli |
| CSB-EP026084HUc7 | Recombinant Human Wee1-like protein kinase (WEE1) | E.coli |
WEE1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP026084MO CSB-BP026084MO CSB-MP026084MO CSB-EP026084MO-B |
Recombinant Mouse Wee1-like protein kinase (Wee1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
WEE1 Proteins for Drosophila melanogaster (Fruit fly)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP026084DLU CSB-EP026084DLU CSB-BP026084DLU CSB-MP026084DLU CSB-EP026084DLU-B |
Recombinant Drosophila melanogaster Wee1-like protein kinase (wee) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
WEE1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP357135SXV CSB-EP357135SXV CSB-BP357135SXV CSB-MP357135SXV CSB-EP357135SXV-B |
Recombinant Schizosaccharomyces pombe Mitosis inhibitor protein kinase wee1 (wee1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
WEE1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP723610RA CSB-EP723610RA CSB-BP723610RA CSB-MP723610RA CSB-EP723610RA-B |
Recombinant Rat Wee1-like protein kinase (Wee1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
WEE1 Proteins for Oryza sativa subsp. japonica (Rice)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP751135OFG CSB-EP751135OFG CSB-BP751135OFG CSB-MP751135OFG CSB-EP751135OFG-B |
Recombinant Oryza sativa subsp. japonica Wee1-like protein kinase (WEE1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
WEE1 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP811852DOA CSB-EP811852DOA CSB-BP811852DOA CSB-MP811852DOA CSB-EP811852DOA-B |
Recombinant Arabidopsis thaliana Wee1-like protein kinase (WEE1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
