USP7

USP7，即泛素特異性肽酶7，別名TEF1、HAUSP、HAFOUS，是一種去泛素化酶，屬于肽酶C19家族，其中包括泛素水解酶。
USP7可通過去泛素化目標蛋白質，如p53（一種腫瘤抑制蛋白）和WASH（內體蛋白質回收所必需的），調節它們的活動，這通過抵消參與相應過程的蛋白質（如HDM2和TRIM27）的相反泛素連接酶活性來實現。
USP7在細胞周期、DNA修復、染色質重塑和表觀遺傳調控中扮演關鍵角色。異常激活或過表達的USP7可能促進腫瘤發生和病毒性疾病，使其成為治療干預的靶點。USP7還與多種疾病相關，包括神經發育障礙等。

熱銷產品

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 7 (USP7),Partial (CSB-EP849973HU)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

USP7 Recombinant Monoclonal Antibody (CSB-RA192026A0HU)

驗證數據

Western Blot
Positive WB detected in: K562 whole cell lysate
All lanes: HAUSP antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 129, 127 kDa
Observed band size: 140 kDa

IHC image of CSB-RA192026A0HU diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA192026A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Immunofluorescence staining of Hela Cells with CSB-RA192026A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

USP7 Antibody

USP7 Protein

USP7 Antibodies

USP7 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA849973LA01HU	USP7 Antibody	Human	ELISA, IHC, IF
CSB-PA849973LB01HU	USP7 Antibody, HRP conjugated	Human	ELISA
CSB-PA849973LC01HU	USP7 Antibody, FITC conjugated	Human
CSB-PA849973LD01HU	USP7 Antibody, Biotin conjugated	Human	ELISA
CSB-RA192026A0HU	USP7 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IF

USP7 Proteins

USP7 Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP700351RA CSB-EP700351RA CSB-BP700351RA CSB-MP700351RA CSB-EP700351RA-B	Recombinant Rat Ubiquitin carboxyl-terminal hydrolase 7 (Usp7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

USP7 Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP721329MO CSB-EP721329MO CSB-BP721329MO CSB-MP721329MO CSB-EP721329MO-B	Recombinant Mouse Ubiquitin carboxyl-terminal hydrolase 7 (Usp7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

USP7 Proteins for Gallus gallus (Chicken)

產品貨號	產品名稱	來源
CSB-YP764911CH CSB-EP764911CH CSB-BP764911CH CSB-MP764911CH CSB-EP764911CH-B	Recombinant Chicken Ubiquitin carboxyl-terminal hydrolase 7 (USP7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

USP7 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP849973HU CSB-BP849973HU CSB-MP849973HU CSB-EP849973HU-B	Recombinant Human Ubiquitin carboxyl-terminal hydrolase 7 (USP7), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP849973HU	Recombinant Human Ubiquitin carboxyl-terminal hydrolase 7 (USP7),Partial	E.coli
CSB-EP849973HU1	Recombinant Human Ubiquitin carboxyl-terminal hydrolase 7 (USP7), partial	E.coli

USP7 Proteins for Drosophila melanogaster (Fruit fly)

產品貨號	產品名稱	來源
CSB-YP894292DLU CSB-EP894292DLU CSB-BP894292DLU CSB-MP894292DLU CSB-EP894292DLU-B	Recombinant Drosophila melanogaster Ubiquitin carboxyl-terminal hydrolase 7 (Usp7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli