UPF1
UPF1 is a protein in humans that is encoded by UPF1 gene. RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors. UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways. Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2. For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed.
UPF1 Antibodies
UPF1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA040201 | UPF1 Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA245266 | UPF1 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA838819LA01HU | UPF1 Antibody | Human | ELISA, IF |
| CSB-PA838819LB01HU | UPF1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA838819LC01HU | UPF1 Antibody, FITC conjugated | Human | |
| CSB-PA838819LD01HU | UPF1 Antibody, Biotin conjugated | Human | ELISA |
UPF1 Proteins
UPF1 Proteins for Dictyostelium discoideum (Slime mold)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP681606DKK CSB-EP681606DKK CSB-BP681606DKK CSB-MP681606DKK CSB-EP681606DKK-B |
Recombinant Dictyostelium discoideum Regulator of nonsense transcripts 1 (upf1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UPF1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP838819HU CSB-EP838819HU CSB-BP838819HU CSB-MP838819HU CSB-EP838819HU-B |
Recombinant Human Regulator of nonsense transcripts 1 (UPF1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UPF1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP872108MO CSB-EP872108MO CSB-BP872108MO CSB-MP872108MO CSB-EP872108MO-B |
Recombinant Mouse Regulator of nonsense transcripts 1 (Upf1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UPF1 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP875473DOA CSB-EP875473DOA CSB-BP875473DOA CSB-MP875473DOA CSB-EP875473DOA-B |
Recombinant Arabidopsis thaliana Regulator of nonsense transcripts 1 homolog (UPF1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UPF1 Proteins for Drosophila melanogaster (Fruit fly)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP896169DLU CSB-EP896169DLU CSB-BP896169DLU CSB-MP896169DLU CSB-EP896169DLU-B |
Recombinant Drosophila melanogaster Regulator of nonsense transcripts 1 homolog (Upf1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
