UBR5
UBR5，即泛素蛋白連接酶E3成分n-識別蛋白5，別名DD5、EDD、HYD、EDD1。UBR5屬于HECT家族的E3泛素蛋白連接酶，具有HECT結構域，能夠通過添加泛素來修飾蛋白質。UBR5能識別特定蛋白質的N端降解信號，并促進這些蛋白質的泛素化和隨后的降解。UBR5參與DNA損傷反應、代謝、轉錄和凋亡的調節，是泛素-蛋白酶體系統（UPS）在癌癥和發育過程中的關鍵調節因子。UBR5的異常表達或突變可能導致細胞內蛋白質的異常積累或降解，影響細胞的正常功能和生理平衡，為腫瘤增殖、轉錄調控和腫瘤免疫逃逸提供有利條件，最終促進腫瘤的發生。
熱銷產品
驗證數據
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using EDD antibody.
Western blot analysis of extracts from A549 cells, using EDD antibody.
Western blot analysis of extracts from HeLa cells (Lane 2), A549 cells (Lane 3) and HepG2 cells (Lane 4), using EDD antiobdy. The lane on the left is treated with systhesized peptide.
UBR5 Antibodies
UBR5 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA083120 | UBR5 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA004376 | UBR5 Antibody | Human | IHC, ELISA |
UBR5 Proteins
UBR5 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP025520HU CSB-EP025520HU CSB-BP025520HU CSB-MP025520HU CSB-EP025520HU-B |
Recombinant Human E3 ubiquitin-protein ligase UBR5 (UBR5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UBR5 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP720310RA CSB-EP720310RA CSB-BP720310RA CSB-MP720310RA CSB-EP720310RA-B |
Recombinant Rat E3 ubiquitin-protein ligase UBR5 (Ubr5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UBR5 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP770457MO CSB-EP770457MO CSB-BP770457MO CSB-MP770457MO CSB-EP770457MO-B |
Recombinant Mouse E3 ubiquitin-protein ligase UBR5 (Ubr5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
