TRPV6
TRPV6，即瞬時受體電位通道家族，Vanilloid亞家族成員6”，別名ECACAC1。它是一種屬于TRP陽離子通道家族的膜蛋白，主要在小腸、腎臟、胎盤、附睪和某些分泌腺等上皮組織中表達。TRPV6的作用機制涉及到對細胞內鈣離子(Ca2+)的調節，通過其通道活性參與鈣離子的選擇性通透，對維持體內鈣平衡和生理功能至關重要。TRPV6基因是維生素D活性形式的直接轉錄靶標，其表達受維生素D水平的調控，以適應機體對鈣離子的需求。此外，TRPV6還可能通過與膜上的其他蛋白質如calmodulin相互作用來實現其功能。TRPV6在生物學上的意義主要體現在其對鈣離子穩態的調控上。它在腸道和腎臟中的功能尤為重要，參與了鈣離子的吸收和重吸收過程，從而幫助維持血鈣水平。TRPV6的功能喪失突變與一些疾病相關，如高鈣尿癥、骨密度降低、體重增長不足、生育能力降低，甚至脫發。此外，TRPV6在一些惡性腫瘤中被發現過度表達，其上調與腫瘤的侵襲性、轉移和不良生存率密切相關，表明TRPV6可能在腫瘤發展中起到促進作用。因此，TRPV6不僅在維持生理功能中發揮關鍵作用，也可能成為治療某些疾病，尤其是癌癥治療的潛在靶點。
熱銷產品
TRPV6 Antibody (CSB-PA861992LA01HU)
驗證數據
IHC image of CSB-PA861992LA01HU diluted at 1:300 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
TRPV6 Antibodies
TRPV6 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA025098GA01HU | TRPV6 Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA861992LA01HU | TRPV6 Antibody | Human | ELISA, IHC |
| CSB-PA861992LB01HU | TRPV6 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA861992LC01HU | TRPV6 Antibody, FITC conjugated | Human | |
| CSB-PA861992LD01HU | TRPV6 Antibody, Biotin conjugated | Human | ELISA |
TRPV6 Proteins
TRPV6 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP861992HU1 CSB-EP861992HU1 CSB-BP861992HU1 CSB-MP861992HU1 CSB-EP861992HU1-B |
Recombinant Human Transient receptor potential cation channel subfamily V member 6 (TRPV6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF861992HU | Recombinant Human Transient receptor potential cation channel subfamily V member 6 (TRPV6) | in vitro E.coli expression system |
| CSB-MP861992HU | Recombinant Human Transient receptor potential cation channel subfamily V member 6 (TRPV6)-VLPs | Mammalian cell |
