TRIP12
E3 ubiquitin-protein ligase TRIP12 is a protein in humans that is encoded by TRIP12 gene. E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A.
TRIP12 Antibodies
TRIP12 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA617924ESR2HU | TRIP12 Antibody | Human | ELISA, IHC |
TRIP12 Proteins
TRIP12 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP617924HU CSB-MP617924HU CSB-EP617924HU-B |
Recombinant Human E3 ubiquitin-protein ligase TRIP12 (TRIP12), partial | Yeast Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP617924HU | Recombinant Human E3 ubiquitin-protein ligase TRIP12 (TRIP12), partial | E.coli |
| CSB-BP617924HU | Recombinant Human E3 ubiquitin-protein ligase TRIP12 (TRIP12), partial | Baculovirus |
