TPX2
TPX2，即微管成核因子，別名DIL2、p100、HCTP4、FLS353、HCA519。TPX2是一種微管相關蛋白，參與微管的成核和組織。TPX2與Ran-GTP的相互作用以及與Aurora A激酶的結合在紡錘體的組裝和形成中發揮重要作用。TPX2在細胞周期運轉過程中起著關鍵作用，特別是在細胞有絲分裂時，TPX2通過結合蛋白激酶Aurora A，促進Aurora A的結構變化，進而影響紡錘體的形成。TPX2的異常表達與多種腫瘤的發生發展相關，包括膀胱癌和宮頸癌，其在腫瘤細胞中的過表達能促進腫瘤細胞的惡性增生及細胞轉移。
熱銷產品
TPX2 Antibody (CSB-PA892151LA01HU)
驗證數據
Western Blot
Positive WB detected in: MCF-7 whole cell lysate
All lanes: TPX2 antibody at 3.5μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 86, 90 kDa
Observed band size: 86 kDa
IHC image of CSB-PA892151LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
TPX2 Antibodies
TPX2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA024139GA01HU | TPX2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA560765 | TPX2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA008292 | TPX2 Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA784922 | TPX2 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA251071 | TPX2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA892151LA01HU | TPX2 Antibody | Human | ELISA, WB, IHC |
| CSB-PA892151LB01HU | TPX2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA892151LC01HU | TPX2 Antibody, FITC conjugated | Human | |
| CSB-PA892151LD01HU | TPX2 Antibody, Biotin conjugated | Human | ELISA |
TPX2 Proteins
TPX2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP892151HU CSB-EP892151HU CSB-BP892151HU CSB-MP892151HU CSB-EP892151HU-B |
Recombinant Human Targeting protein for Xklp2 (TPX2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
