TNFSF14
TNFSF14是腫瘤壞死因子超家族第14個(gè)成員，又稱為HVEML（Herpesvirus entry mediator ligand）或LIGHT，是一個(gè)可以調(diào)節(jié)T細(xì)胞活化的共刺激分子。TNFSF14通過與其3個(gè)不同的受體結(jié)合（皰疹病毒侵入介質(zhì)（HVEM）、淋巴毒素β受體（LTβR）及誘餌受體（TR6）），發(fā)揮不同的生物學(xué)作用。研究發(fā)現(xiàn)，LIGHT在腫瘤細(xì)胞中強(qiáng)制表達(dá)可促進(jìn)淋巴樣結(jié)構(gòu)形成以引導(dǎo)T細(xì)胞聚集與活化，從而導(dǎo)致腫瘤的消退。值得注意的是，TNFSF14在COVID-19感染患者血漿中存在顯著升高，但在其他相關(guān)的肺部感染，例如流感（Flu）病毒和呼吸道合胞病毒（RSV）中則沒有明顯增強(qiáng)，表明其可能是新冠病毒獨(dú)有的作用靶點(diǎn)。CERC-002是一款first-in-class、靶向TNFSF14的全人源單克隆抗體，被開發(fā)用于治療COVID-19相關(guān)的急性呼吸窘迫綜合征（ARDS）和兒童罕見病克羅恩病，其研發(fā)公司Cerecor在2021年5月份被美國(guó)FDA授予CERC-002快速通道。
Recombinant Human TNFSF14 活性蛋白實(shí)驗(yàn)驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized TNFRSF14 (CSB-MP842173HU) at 5 μg/ml can bind TNFSF14, the EC50 is 45.44-53.29 ng/ml.
TNFSF14 Antibodies
TNFSF14 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA06825A0Rb | TNFSF14 Antibody | Human | ELISA, WB, IF |
| CSB-PA023991GA01HU | TNFSF14 Antibody | Human,Mouse,Rat | ELISA |
| CSB-PA616434 | TNFSF14 Antibody | Human | ELISA,IF |
| CSB-PA070140 | TNFSF14 Antibody | Human,Mouse | IF, ELISA |
TNFSF14 Proteins
TNFSF14 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023991HU1 CSB-EP023991HU1 CSB-BP023991HU1 CSB-MP023991HU1 CSB-EP023991HU1-B |
Recombinant Human Tumor necrosis factor ligand superfamily member 14 (TNFSF14), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF023991HU(A4) | Recombinant Human Tumor necrosis factor ligand superfamily member 14 (TNFSF14) | in vitro E.coli expression system |
| CSB-MP023991HU | Recombinant Human Tumor necrosis factor ligand superfamily member 14 (TNFSF14), partial | Mammalian cell |
| CSB-MP023991HUj2 | Recombinant Human Tumor necrosis factor ligand superfamily member 14 (TNFSF14), partial (Active) | Mammalian cell |
| CSB-MP023991HUj7-B | Recombinant Human Tumor necrosis factor ligand superfamily member 14 (TNFSF14), partial,Biotinylated (Active) | Mammalian cell |
TNFSF14 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP879457MO CSB-EP879457MO CSB-BP879457MO CSB-MP879457MO CSB-EP879457MO-B |
Recombinant Mouse Tumor necrosis factor ligand superfamily member 14 (Tnfsf14), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TNFSF14 ELISA Kit
TNFSF14 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL023991HU | Human Tumor necrosis factor ligand superfamily member 14(TNFSF14) ELISA kit | serum, plasma, tissue homogenates. | 0.039 ng/ml |
TNFSF14 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL023991MO | Mouse Tumor necrosis factor ligand superfamily member 14(TNFSF14) ELISA kit | serum, plasma, tissue homogenates | 6.25 pg/mL |
