TNFRSF13B
TNFRSF13B，即腫瘤壞死因子受體超家族成員13B，別名B細(xì)胞活化因子（BAFF）、TALL-1、CD267、TACI配體等。它是一種主要由單核細(xì)胞、樹突狀細(xì)胞及T細(xì)胞產(chǎn)生的細(xì)胞因子，屬于腫瘤壞死因子超家族成員。TNFRSF13B在免疫應(yīng)答中起重要作用，尤其是促進(jìn)B細(xì)胞的成熟和分化，并與自身免疫密切相關(guān)。其作用機(jī)制涉及與其受體TACI、BCMA和BAFFR等結(jié)合，激活下游的信號(hào)傳導(dǎo)途徑，如NF-κB、JAK/STAT等，進(jìn)而影響B(tài)細(xì)胞的存活、增殖和分化。TNFRSF13B在生物學(xué)上的意義非常廣泛，它參與了多種生理和病理過程的調(diào)節(jié)。在正常生理?xiàng)l件下，TNFRSF13B對(duì)于維持B細(xì)胞穩(wěn)態(tài)和抗體產(chǎn)生至關(guān)重要。在病理?xiàng)l件下，TNFRSF13B的異常表達(dá)或功能失調(diào)與多種自身免疫性疾病的發(fā)生發(fā)展有關(guān)，如系統(tǒng)性紅斑狼瘡、類風(fēng)濕關(guān)節(jié)炎等。此外，TNFRSF13B還可能參與某些B細(xì)胞淋巴瘤的發(fā)展。因此，TNFRSF13B是免疫學(xué)研究和相關(guān)疾病治療中的一個(gè)潛在靶點(diǎn)。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
TNFRSF13B Antibody (CSB-PA006292)
驗(yàn)證數(shù)據(jù)
Western Blot analysis of 3T3 cells using CD267 Polyclonal Antibody
Western Blot analysis of NIH-3T3 cells using CD267 Polyclonal Antibody
TNFRSF13B Antibodies
TNFRSF13B for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA023971GA01HU | TNFRSF13B Antibody | Human | ELISA,WB |
| CSB-PA023971DSR2HU | TNFRSF13B Antibody | Human | ELISA, IHC |
| CSB-PA006292 | TNFRSF13B Antibody | Human | WB, ELISA |
TNFRSF13B Proteins
TNFRSF13B Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP023971HU1 CSB-EP023971HU1 CSB-BP023971HU1 CSB-EP023971HU1-B |
Recombinant Human Tumor necrosis factor receptor superfamily member 13B (TNFRSF13B), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-AP002301HU | Recombinant Human Tumor necrosis factor receptor superfamily member 13B protein (TNFRSF13B), partial (Active) | E.Coli |
| CSB-CF023971HU | Recombinant Human Tumor necrosis factor receptor superfamily member 13B (TNFRSF13B) | in vitro E.coli expression system |
TNFRSF13B Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP863678MO CSB-EP863678MO CSB-BP863678MO CSB-MP863678MO CSB-EP863678MO-B |
Recombinant Mouse Tumor necrosis factor receptor superfamily member 13B (Tnfrsf13b), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TNFRSF13B ELISA Kit
TNFRSF13B ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL023971HU | Human Tumor necrosis factor receptor superfamily member 13B(TNFRSF13B) ELISA kit | serum, plasma, tissue homogenates | 19.5 pg/ml |
TNFRSF13B ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL023971MO | Mouse Tumor necrosis factor receptor superfamily member 13B(TNFRSF13B) ELISA kit | serum, plasma, tissue homogenates | 19.5 pg/ml |
