TNFR1

TNFR1（Tumor Necrosis Factor Receptor 1），也稱為TNF-R55或CD120a，是一種受體蛋白，它與腫瘤壞死因子α（TNF-α）相互作用并在多種生理和病理過程中發揮關鍵作用。包含一個細胞外域、一個跨膜域和一個細胞內域。細胞外域與TNF-α結合，觸發信號傳導。細胞內域包含一個死亡結構域（Death Domain），它在啟動凋亡（細胞自我毀滅）和其他細胞信號傳導通路中發揮關鍵作用。TNFR1主要通過與其配體TNF-α相互作用來介導多種生物學效應。當TNF-α與TNFR1結合時，它可以引發一系列信號傳導事件，包括NF-κB（核因子-κB）的激活和JNK（c-Jun N-末端激酶）通路的激活。在自身免疫疾病和炎癥性疾病的治療中，研究人員已經開發出一些生物制劑，如抗TNF藥物（如英夫利麥、阿達木單抗等），用于減輕癥狀并減緩疾病進展。這些藥物通過抑制TNF-α與TNFR1的結合，降低炎癥反應。此外，TNFR1還涉及到腫瘤的發展和抵抗性，因此在癌癥治療領域也具有潛在的應用前景。

熱銷產品

Recombinant Human Tumor necrosis factor receptor superfamily member 1A(TNFRSF1A),partial (Active) CSB-MP023977HU1

驗證數據

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA

High Purity Validated of CSB-MP023977HU1

Activity: Measured by its binding ability in a functional ELISA. Immobilized TNF-α (CSB-YP023955HU) at 5 μg/ml can bind human TNFR1, the EC₅₀ is 7.799-10.90 ng/ml.

ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized LTA (CSB-MP013218HU) at 5 μg/ml can bind human TNFR1, the EC₅₀ is 4.409-6.797 ng/ml.

TNFR1 Antibody

TNFR1 Protein

TNFR1 ELISA Kit

TNFR1 Antibodies

TNFR1 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA023977GA01HU	TNFRSF1A Antibody	Human	ELISA,WB
CSB-PA973584	TNFRSF1A Antibody	Human,Mouse	ELISA,IHC
CSB-PA050275	TNFRSF1A Antibody	Human,Mouse,Rat	IHC, ELISA
CSB-PA023977LA01HU	TNFRSF1A Antibody	Human	ELISA, WB, IHC, IF
CSB-PA023977LB01HU	TNFRSF1A Antibody, HRP conjugated	Human	ELISA
CSB-PA023977LC01HU	TNFRSF1A Antibody, FITC conjugated	Human
CSB-PA023977LD01HU	TNFRSF1A Antibody, Biotin conjugated	Human	ELISA

TNFR1 Proteins

TNFR1 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-EP023977HU1 CSB-BP023977HU1 CSB-EP023977HU1-B	Recombinant Human Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), partial	E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-RP072244h	Recombinant Human Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), partial	E.coli
CSB-AP002361HU	Recombinant Human Tumor necrosis factor receptor superfamily member 1A protein (TNFRSF1A), partial (Active)	E.Coli
CSB-CF023977HU	Recombinant Human Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)	in vitro E.coli expression system
CSB-AP004971HU	Recombinant Human Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), partial (Active)	E.coli
CSB-MP023977HU1	Recombinant Human Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), partial (Active)	Mammalian cell
CSB-YP023977HU1	Recombinant Human Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), partial	Yeast

TNFR1 Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP023977MO1 CSB-EP023977MO1 CSB-BP023977MO1 CSB-MP023977MO1 CSB-EP023977MO1-B	Recombinant Mouse Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF023977MO	Recombinant Mouse Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a)	in vitro E.coli expression system

TNFR1 Proteins for Bos taurus (Bovine)

產品貨號	產品名稱	來源
CSB-YP023977BO1 CSB-EP023977BO1 CSB-BP023977BO1 CSB-MP023977BO1 CSB-EP023977BO1-B	Recombinant Bovine Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF023977BO	Recombinant Bovine Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)	in vitro E.coli expression system

TNFR1 ELISA Kit

TNFR1 ELISA Kit for Homo sapiens (Human)

產品貨號	產品名稱	樣本類型	靈敏度
CSB-E04736h	Human Tumor necrosis factor soluble receptor Ⅰ,TNFsR-ⅠELISA KIT	serum, plasma, tissue homogenates, urine	65 pg/mL
CSB-E04736h-IS	Human Tumor necrosis factor soluble receptor Ⅰ,TNFsR-ⅠELISA KIT	serum, plasma, tissue homogenates, urine, saliva, cell culture supernates	1.95 pg/ml