THPO
THPO，全稱促血小板生成素，是一種由人體內THPO基因編碼的糖蛋白激素，也被稱為巨核細胞生長衍生因子（MGDF）。它主要由腎臟和肝臟分泌，能夠刺激巨核細胞的形成和分化，進而促進血小板的生成。THPO通過與MPL受體結合，激活下游信號通路，促進巨核細胞增殖、分化和成熟，最終形成血小板。在臨床上，THPO主要用于治療血小板減少癥，如原發免疫性血小板減少癥（ITP）和化療后血小板恢復，以及預防腫瘤治療引起的血小板減少。目前，全球已有多種THPO類似物和受體激動劑獲批上市，如重組人血小板生成素（rhTPO）、羅普司亭、艾曲泊帕等，這些藥物通過不同方式激活THPO受體，提高血小板計數，改善患者的出血風險。此外，THPO在肝病和移植領域也有應用，如肝衰竭時TPO水平下降可作為預后標志物，而在干細胞移植中，TPO預處理可增強造血干細胞歸巢效率。目前，科學家們還在研究THPO在腫瘤治療副作用、骨髓纖維化等疾病中的應用，以及開發新型THPO類似物和受體激動劑，以進一步提高療效和安全性。
熱銷產品
Recombinant Human Thrombopoietin (THPO) (Active) (CSB-MP023509HU(A4))
驗證數據
-SDS.jpg)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
-AC1.jpg)
Activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of MO7e cells is 0.4353 - 1.089 ng/mL.
驗證數據
Western Blot analysis of MCF-7 cells using TPO Polyclonal Antibody.
Human Thrombopoietin,TPO ELISA kit (CSB-E04745h)
驗證數據
貨號：CSB-E04745h
規格：96T/48T
靈敏度：1.56 pg/mL
檢測范圍：6.25 pg/mL-400 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
THPO Antibodies
THPO for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA005677 | THPO Antibody | Human | WB, ELISA |
THPO for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA07649A0Rb | Thpo Antibody | Rat, Mouse, Human | ELISA, WB |
| CSB-PA07649B0Rb | Thpo Antibody, HRP conjugated | Rat | ELISA |
THPO Proteins
THPO Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023509HU CSB-BP023509HU CSB-MP023509HU CSB-EP023509HU-B |
Recombinant Human Thrombopoietin (THPO)，partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP023509HU | Recombinant Human Thrombopoietin (THPO)，partial | E.coli |
| CSB-AP003971HU | Recombinant Human Thrombopoietin (THPO) (Active) | Mammalian cell |
| CSB-EP023509HUc7 | Recombinant Human Thrombopoietin (THPO), partial | E.coli |
| CSB-MP023509HU(A4) | Recombinant Human Thrombopoietin (THPO) (Active) | Mammalian cell |
| CSB-BP023509HU(A4) | Recombinant Human Thrombopoietin (THPO) | Baculovirus |
THPO Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023509PI CSB-EP023509PI CSB-BP023509PI CSB-MP023509PI CSB-EP023509PI-B |
Recombinant Pig Thrombopoietin (THPO), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
THPO Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023509MO CSB-EP023509MO CSB-BP023509MO CSB-MP023509MO CSB-EP023509MO-B |
Recombinant Mouse Thrombopoietin (Thpo) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP003451MO | Recombinant Mouse Thrombopoietin protein (Thpo), partial (Active) | E.Coli |
THPO Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023509DO CSB-EP023509DO CSB-BP023509DO CSB-MP023509DO CSB-EP023509DO-B |
Recombinant Dog Thrombopoietin (THPO) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
THPO Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023509RA CSB-EP023509RA CSB-BP023509RA CSB-MP023509RA CSB-EP023509RA-B |
Recombinant Rat Thrombopoietin (Thpo) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-RP076444r | Recombinant Rat Thrombopoietin (Thpo), partial | E.coli |
THPO ELISA Kit
THPO ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04745h | Human Thrombopoietin,TPO ELISA kit | serum, plasma | 1.56 pg/mL |
THPO ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04746m | Mouse Thrombopoietin,TPO ELISA kit | serum, plasma, tissue homogenates | 1.56 pg/mL |
THPO ELISA Kit for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E07378r | Rat Thrombopoietin,TPO ELISA kit | serum, plasma, tissue homogenates | 0.01 ng/ml |
