TEAD1
TEAD1，即睪丸特異性轉錄增強子1，別名TEF-1、TEF-2、TEAD4、RTEF-1等。它是一種轉錄因子，屬于TEA/ATTS家族成員，由人體細胞自身的基因編碼。TEAD1在多種組織中都有表達，尤其在心臟、肌肉和生殖系統等組織中表達較高。TEAD1的作用機制主要是通過與DNA上的特定序列結合，調控下游基因的轉錄。TEAD1可以與多種轉錄共激活因子如YAP1相互作用，形成復合體，進而激活或抑制特定基因的表達。TEAD1在生物學上的意義非常廣泛，它參與了多種細胞生命活動的調控，包括細胞增殖、分化、遷移和凋亡等。TEAD1通過參與調控細胞周期相關基因的表達，影響細胞的增殖和周期進程。此外，TEAD1還參與了心臟和血管的發育、肌肉的再生以及生殖細胞的分化等過程。在腫瘤細胞中，TEAD1的異常表達與腫瘤的發生發展密切相關，其功能異?？赡軐е录毎麗盒栽鲋澈娃D移。因此，TEAD1是細胞生物學和疾病研究中的一個重要轉錄因子，也是藥物開發和疾病治療中的潛在靶點。
熱銷產品
Recombinant Human Transcriptional enhancer factor TEF-1 (TEAD1), partial (CSB-EP023363HU1)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TEAD1 Antibody (CSB-PA023363DSR2HU)
驗證數據
Western Blot
Positive WB detected in: HepG2 whole cell lysate, MCF-7 whole cell lysate, PC-3 whole cell lysate
All lanes: TEAD1 antibody at 3.6µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 48 kDa
Observed band size: 48 kDa
IHC image of CSB-PA023363DSR2HU diluted at 1:441 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of A549 cells with CSB-PA023363DSR2HU at 1:147, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
TEAD1 Antibodies
TEAD1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA023363GA01HU | TEAD1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA023363DSR2HU | TEAD1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA921314 | TEAD1 Antibody | Human | ELISA,WB |
| CSB-PA050232 | TEAD1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
TEAD1 Proteins
TEAD1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP023363MO CSB-EP023363MO CSB-BP023363MO CSB-MP023363MO CSB-EP023363MO-B |
Recombinant Mouse Transcriptional enhancer factor TEF-1 (Tead1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TEAD1 Proteins for Homo sapiens (Human)
