TCF7L2
Transcription factor 7-like 2 is a protein in humans that is encoded by TCF7L2 gene. Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
TCF7L2 Antibodies
TCF7L2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA023307GA01HU | TCF7L2 Antibody | Human,Mouse,Rat | ELISA,WB |
TCF7L2 Proteins
TCF7L2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP846068MO CSB-EP846068MO CSB-BP846068MO CSB-MP846068MO CSB-EP846068MO-B |
Recombinant Mouse Transcription factor 7-like 2 (Tcf7l2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TCF7L2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP889079HU CSB-BP889079HU CSB-MP889079HU CSB-EP889079HU-B |
Recombinant Human Transcription factor 7-like 2 (TCF7L2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP889079HU | Recombinant Human Transcription factor 7-like 2 (TCF7L2), partial | E.coli |
