TALDO1
TALDO1，即轉(zhuǎn)醛醇酶1，別名包括Transaldolase 1、TAL、TALDO、TALDOR等。它是一種在人體多種組織中表達(dá)的酶，由TALDO1基因編碼，位于染色體11上 。TALDO1的作用機制主要是作為非氧化戊糖磷酸途徑的關(guān)鍵酶，催化景天庚酮糖7-磷酸和D-甘油醛3-磷酸可逆轉(zhuǎn)化為赤蘚糖4-磷酸和β-D-果糖6-磷酸，為核酸合成提供核糖5-磷酸，為脂質(zhì)生物合成提供NADPH 。TALDO1參與維持谷胱甘肽的還原狀態(tài)，保護(hù)巰基和細(xì)胞完整性免受氧自由基的侵害，還參與多種代謝途徑的協(xié)調(diào)。TALDO1的功能異常與多種疾病有關(guān)，例如轉(zhuǎn)醛醇酶1缺乏癥、多發(fā)性硬化癥、肝病、肝硬化、肝癌等 。此外，TALDO1的表達(dá)水平在某些腫瘤中發(fā)生改變，可能影響腫瘤細(xì)胞的增殖、侵襲和轉(zhuǎn)移等惡性行為 。因此，TALDO1是藥物開發(fā)和疾病治療中的一個潛在靶點。
熱銷產(chǎn)品
Recombinant Human Transaldolase (TALDO1), partial (CSB-RP042754h)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TALDO1 Antibody (CSB-PA04275A0Rb)
驗證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA04275A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA04275A0Rb at dilution of 1:100
Western blot
All lanes: TALDO1 antibody at 0.1µg/ml
Lane 1: Human placenta tissue
Lane 2: Hela whole cell lysate
Lane 3: Jurkat whole cell lysate
Lane 4: A375 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 38 kDa
Observed band size: 38 kDa
TALDO1 Antibodies
TALDO1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA04275A0Rb | TALDO1 Antibody | Human | ELISA, WB, IHC |
| CSB-PA023112GA01HU | TALDO1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA977634 | TALDO1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA217736 | TALDO1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
TALDO1 Proteins
TALDO1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP023112HU CSB-EP023112HU-B |
Recombinant Human Transaldolase (TALDO1) | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-RP042754h | Recombinant Human Transaldolase (TALDO1), partial | E.coli |
