STK33
STK33，即絲氨酸/蘇氨酸激酶33，它是一種在人體多種組織中表達(dá)的蛋白激酶，屬于鈣/鈣調(diào)蛋白依賴性激酶家族成員。STK33在細(xì)胞中的表達(dá)受細(xì)胞密度控制，并且在頭頸腫瘤等手術(shù)切除標(biāo)本中的表達(dá)量顯著高于正?；虬┡越M織。其作用機(jī)制涉及自磷酸化功能，能夠?qū)ο掠位蛉鏥imentin蛋白進(jìn)行磷酸化修飾，影響其生物學(xué)功能。STK33還可能通過(guò)非激酶活性依賴途徑影響C-Myc基因的轉(zhuǎn)錄作用。在信號(hào)通路方面，STK33與ERK1/2信號(hào)通路存在交互作用，可能參與調(diào)控細(xì)胞增殖、侵襲和轉(zhuǎn)移。STK33的生物學(xué)意義在于其在腫瘤細(xì)胞的增殖、侵襲與轉(zhuǎn)移等過(guò)程中的重要作用，尤其在KRAS突變相關(guān)的腫瘤中，STK33的表達(dá)與腫瘤細(xì)胞的生物學(xué)行為密切相關(guān)。因此，STK33被認(rèn)為是多種癌癥治療的潛在靶點(diǎn)。
熱銷產(chǎn)品
STK33 Recombinant Monoclonal Antibody (CSB-RA207790A0HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA207790A0HU diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
STK33 Antibodies
STK33 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA022848GA01HU | STK33 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA287139 | STK33 Antibody | Human | ELISA,WB |
| CSB-PA004188 | STK33 Antibody | Human | WB, IHC, ELISA |
| CSB-PA108943 | STK33 Antibody | Human | ELISA,IHC |
| CSB-PA291750 | STK33 Antibody | Human | ELISA,IHC |
| CSB-PA861179LA01HU | STK33 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA861179LD01HU | STK33 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA861179LB01HU | STK33 Antibody, HRP conjugated | Human | ELISA |
| CSB-RA207790A0HU | STK33 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
STK33 Proteins
STK33 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP861179HU CSB-EP861179HU CSB-BP861179HU CSB-MP861179HU CSB-EP861179HU-B |
Recombinant Human Serine/threonine-protein kinase 33 (STK33) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
