STAT3
STAT3，即信號(hào)轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子3，別名包括急性調(diào)節(jié)蛋白、信號(hào)轉(zhuǎn)導(dǎo)激活因子、亞油酸誘導(dǎo)蛋白等。STAT3是一種轉(zhuǎn)錄因子，廣泛存在于多種細(xì)胞類型中，由人體細(xì)胞自身的基因編碼。其作用機(jī)制主要是在細(xì)胞接收到外部信號(hào)，如細(xì)胞因子、生長(zhǎng)因子或其他刺激后，被激活的酪氨酸激酶磷酸化，形成二聚體，隨后轉(zhuǎn)移到細(xì)胞核內(nèi)調(diào)控特定基因的表達(dá)。STAT3的激活涉及JAK/STAT、IL-6/STAT3等信號(hào)通路，其中Janus激酶（JAK）首先被激活并磷酸化STAT3，導(dǎo)致其同源二聚化和核內(nèi)轉(zhuǎn)位。STAT3在生物學(xué)上的意義非常廣泛，它參與調(diào)節(jié)細(xì)胞的多種生理過程，包括細(xì)胞增殖、分化、遷移、凋亡以及免疫應(yīng)答等。STAT3的激活對(duì)于維持細(xì)胞穩(wěn)態(tài)和適應(yīng)外界變化至關(guān)重要。此外，STAT3在多種疾病的發(fā)生發(fā)展中也扮演著關(guān)鍵角色，尤其是在腫瘤發(fā)展中，STAT3的持續(xù)激活與腫瘤細(xì)胞的增殖、存活、血管生成和免疫逃逸等密切相關(guān)。因此，STAT3成為了癌癥治療中的一個(gè)重要靶點(diǎn)。在自身免疫性疾病、炎癥反應(yīng)和組織修復(fù)中，STAT3的調(diào)節(jié)作用同樣不容忽視，靶向STAT3的干預(yù)策略可能為這些疾病的治療提供新的途徑。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
-B-SDS.jpg)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
STAT3 Recombinant Monoclonal Antibody (CSB-RA546821A0HU)
驗(yàn)證數(shù)據(jù)
Overlay histogram showing Hela cells stained with CSB-RA546821A0HU (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1μg/1*106 cells) for 1 h at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1μg/1*106 cells) used under the same conditions. Acquisition of >10,000 events was performed.
STAT3 Antibodies
STAT3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA022812GA01HU | STAT3 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA954939 | Phospho-STAT3 (Tyr705) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA699573 | Phospho-STAT3 (Ser727) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA088158 | STAT3 (Ab-727) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA586999 | STAT3 (Ab-705) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA000621 | Phospho-STAT3 (S727) Antibody | Human,Mouse,Rat,Monkey | WB, IHC, IP, ELISA |
| CSB-PA000622 | Phospho-STAT3 (Y705) Antibody | Human, Mouse, Rat | WB, IHC, IP, ELISA |
| CSB-PA004173 | STAT3 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA004174 | STAT3 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA050164 | STAT3 Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
| CSB-PA080245 | STAT3 Antibody | Human | WB, IHC |
| CSB-PA022812LA01HU | STAT3 Antibody | Human | ELISA, IHC, IF, IP |
| CSB-PA022812LB01HU | STAT3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA022812LC01HU | STAT3 Antibody, FITC conjugated | Human | |
| CSB-PA022812LD01HU | STAT3 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA022812A727phHU | Phospho-STAT3 (S727) Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IP |
| CSB-RA022812A705phHU | Phospho-STAT3 (Tyr705) Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
| CSB-RA546821A0HU | STAT3 Recombinant Monoclonal Antibody | Human | ELISA, FC |
| CSB-RA229700A0HU | STAT3 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
| CSB-RA188270A0HU | STAT3 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
| CSB-RA022812MA1HU | STAT3 Recombinant Monoclonal Antibody | Human | ELISA |
STAT3 Proteins
STAT3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022812HU CSB-BP022812HU CSB-MP022812HU CSB-EP022812HU-B |
Recombinant Human Signal transducer and activator of transcription 3 (STAT3), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP022812HU | Recombinant Human Signal transducer and activator of transcription 3 (STAT3), partial | E.coli |
| CSB-YP022812HU(A4) | Recombinant Human Signal transducer and activator of transcription 3 (STAT3) | Yeast |
| CSB-EP022812HU(A4) | Recombinant Human Signal transducer and activator of transcription 3 (STAT3) | E.coli |
| CSB-BP022812HU(A4) CSB-MP022812HU(A4) |
Recombinant Human Signal transducer and activator of transcription 3 (STAT3) | Baculovirus Mammalian cell |
| CSB-EP022812HU(A4)-B | Recombinant Human Signal transducer and activator of transcription 3 (STAT3),Biotinylated | E.coli |
| CSB-EP022812HU2 | Recombinant Human Signal transducer and activator of transcription 3 (STAT3), partial | E.coli |
STAT3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022812MO CSB-EP022812MO CSB-BP022812MO CSB-MP022812MO CSB-EP022812MO-B |
Recombinant Mouse Signal transducer and activator of transcription 3 (Stat3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAT3 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022812RA CSB-EP022812RA CSB-BP022812RA CSB-MP022812RA CSB-EP022812RA-B |
Recombinant Rat Signal transducer and activator of transcription 3 (Stat3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAT3 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022812BO CSB-EP022812BO CSB-BP022812BO CSB-MP022812BO CSB-EP022812BO-B |
Recombinant Bovine Signal transducer and activator of transcription 3 (STAT3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAT3 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP624331PI CSB-EP624331PI CSB-BP624331PI CSB-MP624331PI CSB-EP624331PI-B |
Recombinant Pig Signal transducer and activator of transcription 3 (STAT3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAT3 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP728573CH CSB-EP728573CH CSB-BP728573CH CSB-MP728573CH CSB-EP728573CH-B |
Recombinant Chicken Signal transducer and activator of transcription 3 (STAT3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
