STAMBP
STAMBP，全稱為STAM結合蛋白，是一種去泛素化酶，在細胞表面受體運輸中發揮關鍵作用。它具有多個別名，包括AMSH、MGC126516和MGC126518。STAMBP通過催化K63連接型泛素鏈的斷裂，參與ESCRT介導的細胞表面受體回收過程。研究發現，STAMBP的MIT結構域對其去泛素化酶活性具有自抑制功能，這一發現為理解STAMBP在膜受體轉運過程中的功能提供了新的視角。此外，STAMBP還與多種疾病密切相關，如三陰性乳腺癌（TNBC），其在腫瘤發生發展中扮演重要角色。目前，針對STAMBP的藥物研發取得了一定進展，例如，STAMBP抑制劑BC-1471已被發現可以抑制MDA-MB-231細胞的生長，盡管效果尚不顯著，但為開發更有效的STAMBP抑制劑提供了重要線索。未來，深入探究STAMBP的功能及其在疾病中的作用機制，將有助于開發更精準的治療策略。
熱銷產品
STAMBP Antibody (CSB-PA022794HA01HU)
驗證數據
Western blot
All lanes: STAMBP antibody at 12µg/ml
Lane 1: Jurkat whole cell lysate
Lane 2: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 49, 40 kDa
Observed band size: 49 kDa
Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA022794HA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA022794HA01HU at dilution of 1:100
STAMBP Antibodies
STAMBP for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA022794GA01HU | STAMBP Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA022794HA01HU | STAMBP Antibody | Human | ELISA, WB, IHC |
| CSB-PA477062 | STAMBP Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA078977 | STAMBP Antibody | Human,Mouse,Rat | ELISA,IHC |
STAMBP Proteins
STAMBP Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP022794HU CSB-EP022794HU CSB-BP022794HU CSB-MP022794HU CSB-EP022794HU-B |
Recombinant Human STAM-binding protein (STAMBP) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAMBP Proteins for Xenopus laevis (African clawed frog)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP731019XBE CSB-EP731019XBE CSB-BP731019XBE CSB-MP731019XBE CSB-EP731019XBE-B |
Recombinant Xenopus laevis STAM-binding protein-like (stambp) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAMBP Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP848124RA CSB-EP848124RA CSB-BP848124RA CSB-MP848124RA CSB-EP848124RA-B |
Recombinant Rat STAM-binding protein (Stambp) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAMBP Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP887415MO CSB-EP887415MO CSB-BP887415MO CSB-MP887415MO CSB-EP887415MO-B |
Recombinant Mouse STAM-binding protein (Stambp) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
