SMURF2
E3 ubiquitin-protein ligase SMURF2 is a protein in humans that is encoded by SMURF2 gene. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2.
SMURF2 Antibodies
SMURF2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA967268 | SMURF2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA872532EA01HU | SMURF2 Antibody | Human | ELISA, IHC |
| CSB-PA872532ED01HU | SMURF2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA872532EC01HU | SMURF2 Antibody, FITC conjugated | Human | |
| CSB-PA872532EB01HU | SMURF2 Antibody, HRP conjugated | Human | ELISA |
SMURF2 Proteins
SMURF2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP021861MO CSB-EP021861MO CSB-BP021861MO CSB-MP021861MO CSB-EP021861MO-B |
Recombinant Mouse E3 ubiquitin-protein ligase SMURF2 (Smurf2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SMURF2 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP021861DIL CSB-EP021861DIL CSB-BP021861DIL CSB-MP021861DIL CSB-EP021861DIL-B |
Recombinant Danio rerio E3 ubiquitin-protein ligase SMURF2 (smurf2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SMURF2 Proteins for Xenopus laevis (African clawed frog)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP647195XBE CSB-EP647195XBE CSB-BP647195XBE CSB-MP647195XBE CSB-EP647195XBE-B |
Recombinant Xenopus laevis E3 ubiquitin-protein ligase SMURF2 (smurf2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SMURF2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP872532HU | Recombinant Human E3 ubiquitin-protein ligase SMURF2 (SMURF2) | Yeast |
| CSB-EP872532HU | Recombinant Human E3 ubiquitin-protein ligase SMURF2 (SMURF2) | E.coli |
| CSB-BP872532HU CSB-MP872532HU CSB-EP872532HU-B |
Recombinant Human E3 ubiquitin-protein ligase SMURF2 (SMURF2) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP872532HUa0 | Recombinant Human E3 ubiquitin-protein ligase SMURF2 (SMURF2) | E.coli |
