SLC30A8
SLC30A8，也被稱為鋅轉(zhuǎn)運(yùn)蛋白8。該蛋白主要在胰島β細(xì)胞中表達(dá)，負(fù)責(zé)將鋅離子轉(zhuǎn)運(yùn)至胰島素分泌顆粒中，參與胰島素的合成、儲(chǔ)存和分泌過(guò)程。研究表明，ZnT8蛋白的功能失活可通過(guò)增強(qiáng)胰島素分泌預(yù)防糖尿病。例如，SLC30A8基因的罕見功能缺失等位基因p.Arg138*在芬蘭西部富集，可預(yù)防2型糖尿病。研究發(fā)現(xiàn)，該等位基因?qū)е耂LC30A8表達(dá)減少，進(jìn)而增加葡萄糖反應(yīng)性和胰島素原轉(zhuǎn)換，從而預(yù)防糖尿病。此外，ZnT8蛋白也被認(rèn)為是2型糖尿病中維持胰島素分泌能力的治療靶點(diǎn)。目前，研究人員正在探索抑制ZnT8蛋白功能的藥物，以預(yù)防或治療2型糖尿病。
熱銷產(chǎn)品
Recombinant Human Proton-coupled zinc antiporter SLC30A8 (SLC30A8) (CSB-CF818247HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
SLC30A8 Antibody (CSB-PA818247LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA818247LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA818247LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
SLC30A8 Antibodies
SLC30A8 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA021573GA01HU | SLC30A8 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA007754 | SLC30A8 Antibody | Human | WB, ELISA |
| CSB-PA818247LA01HU | SLC30A8 Antibody | Human | ELISA, IHC, IF |
| CSB-PA818247LC01HU | SLC30A8 Antibody, FITC conjugated | Human | |
| CSB-PA818247LD01HU | SLC30A8 Antibody, Biotin conjugated | Human | ELISA |
SLC30A8 Proteins
SLC30A8 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP818247HU1 CSB-BP818247HU1 CSB-MP818247HU1 CSB-EP818247HU1-B |
Recombinant Human Proton-coupled zinc antiporter SLC30A8 (SLC30A8), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF818247HU | Recombinant Human Proton-coupled zinc antiporter SLC30A8 (SLC30A8) | in vitro E.coli expression system |
| CSB-MP818247HU | Recombinant Human Proton-coupled zinc antiporter SLC30A8 (SLC30A8)-VLPs | Mammalian cell |
| CSB-EP818247HU1 | Recombinant Human Proton-coupled zinc antiporter SLC30A8 (SLC30A8), partial | E.coli |
SLC30A8 ELISA Kit
SLC30A8 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL021573HU | Human Zinc transporter 8(SLC30A8) ELISA kit |
