SLC25A5
SLC25A5，全稱為溶質(zhì)載體家族25成員5（Solute Carrier Family 25 Member 5），也被稱為腺苷三磷酸轉(zhuǎn)運(yùn)蛋白2（Adenine Nucleotide Translocator 2）。該蛋白主要存在于線粒體內(nèi)膜，負(fù)責(zé)ADP和ATP在細(xì)胞質(zhì)和線粒體基質(zhì)之間的轉(zhuǎn)運(yùn)，是能量代謝的關(guān)鍵環(huán)節(jié)。SLC25A5蛋白的表達(dá)受到多種因素的調(diào)控，其功能與細(xì)胞的能量狀態(tài)密切相關(guān)。研究表明，SLC25A5蛋白的表達(dá)水平與多種疾病的發(fā)生發(fā)展有關(guān)，如高血壓和短指癥（HTNB），以及結(jié)腸癌等。在HTNB中，SLC25A5基因的突變會導(dǎo)致線粒體功能異常，進(jìn)而引發(fā)高血壓和骨骼發(fā)育異常。此外，SLC25A5蛋白的表達(dá)下調(diào)還與腫瘤細(xì)胞的生長和存活相關(guān)。
基于SLC25A5蛋白的功能和疾病關(guān)聯(lián)性，研究人員正在探索其作為藥物靶點的可能性，以期開發(fā)新的治療策略。目前，已有針對SLC25A5蛋白的藥物研發(fā)正在進(jìn)行中，包括小分子抑制劑和基因治療等。這些研究有望為相關(guān)疾病的治療提供新的選擇。
熱銷產(chǎn)品
SLC25A5 Antibody (CSB-PA021518LA01HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: 293T whole cell lysate
All lanes: SLC25A5 antibody at 3.5μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 33 kDa
Observed band size: 33 kDa
IHC image of CSB-PA021518LA01HU diluted at 1:700 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
SLC25A5 Antibodies
SLC25A5 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA021518LA01HU | SLC25A5 Antibody | Human | ELISA, WB, IHC |
| CSB-PA021518LB01HU | SLC25A5 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA021518LC01HU | SLC25A5 Antibody, FITC conjugated | Human |
SLC25A5 Proteins
SLC25A5 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP021518MO1 CSB-EP021518MO1 CSB-BP021518MO1 CSB-MP021518MO1 CSB-EP021518MO1-B |
Recombinant Mouse ADP/ATP translocase 2 (Slc25a5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF021518MO | Recombinant Mouse ADP/ATP translocase 2 (Slc25a5) | in vitro E.coli expression system |
SLC25A5 Proteins for Tachyglossus aculeatus aculeatus (Australian echidna)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP021518TKU1 CSB-EP021518TKU1 CSB-BP021518TKU1 CSB-MP021518TKU1 CSB-EP021518TKU1-B |
Recombinant Tachyglossus aculeatus aculeatus ADP/ATP translocase 2 (SLC25A5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF021518TKU | Recombinant Tachyglossus aculeatus aculeatus ADP/ATP translocase 2 (SLC25A5) | in vitro E.coli expression system |
SLC25A5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP021518HU1 CSB-EP021518HU1 CSB-BP021518HU1 CSB-MP021518HU1 CSB-EP021518HU1-B |
Recombinant Human ADP/ATP translocase 2 (SLC25A5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF021518HU | Recombinant Human ADP/ATP translocase 2 (SLC25A5) | in vitro E.coli expression system |
SLC25A5 Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP735671PYX1 CSB-EP735671PYX1 CSB-BP735671PYX1 CSB-MP735671PYX1 CSB-EP735671PYX1-B |
Recombinant Pongo abelii ADP/ATP translocase 2 (SLC25A5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF735671PYX | Recombinant Pongo abelii ADP/ATP translocase 2 (SLC25A5) | in vitro E.coli expression system |
SLC25A5 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP823367BO1 CSB-EP823367BO1 CSB-BP823367BO1 CSB-MP823367BO1 CSB-EP823367BO1-B |
Recombinant Bovine ADP/ATP translocase 2 (SLC25A5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF823367BO | Recombinant Bovine ADP/ATP translocase 2 (SLC25A5) | in vitro E.coli expression system |
