SIRT7
SIRT7，全稱為NAD+依賴性組蛋白去乙酰化酶SIRT7，是sirtuin家族的一員，該家族在調節多種生物學過程中發揮作用，包括基因組穩定性、代謝途徑、應激反應和腫瘤發生。SIRT7蛋白主要位于細胞核，是一種高度特異性的H3K18Ac（組蛋白H3的第18位賴氨酸殘基乙酰化）去乙酰化酶。近年來的研究發現，SIRT7蛋白可以通過多種途徑參與調控核糖體RNA轉錄、細胞代謝、細胞應激以及DNA損傷修復等生理過程。
SIRT7還與衰老、心臟疾病及脂肪肝等密切相關。特別是SIRT7在多種腫瘤如肝癌、胃癌、乳腺癌、膀胱癌、結直腸癌、胰腺癌和頭頸鱗狀細胞癌等發生發展中起著重要的調節作用。越來越多的證據表明，SIRT7蛋白的基本細胞程序功能對于致癌演變以及腫瘤生物學有重要的影響，因此SIRT7蛋白有望成為表觀遺傳藥物治療新靶點。
熱銷產品
Recombinant Human NAD-dependent protein deacetylase sirtuin-7 (SIRT7) (CSB-EP885703HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
SIRT7 Antibody (CSB-PA885703LA01HU)
驗證數據
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA885703LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA885703LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
SIRT7 Antibodies
SIRT7 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA021345GA01HU | SIRT7 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA555914 | SIRT7 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA885703LA01HU | SIRT7 Antibody | Human | ELISA, IHC, IF |
| CSB-PA885703LB01HU | SIRT7 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA885703LC01HU | SIRT7 Antibody, FITC conjugated | Human | |
| CSB-PA885703LD01HU | SIRT7 Antibody, Biotin conjugated | Human | ELISA |
SIRT7 Proteins
SIRT7 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP885703HU CSB-BP885703HU CSB-MP885703HU CSB-EP885703HU-B |
Recombinant Human NAD-dependent protein deacetylase sirtuin-7 (SIRT7) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP885703HU | Recombinant Human NAD-dependent protein deacetylase sirtuin-7 (SIRT7) | E.coli |
