SETDB1
Histone-lysine N-methyltransferase SETDB1 is a protein in humans that is encoded by SETDB1 gene. Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells.
SETDB1 Antibodies
SETDB1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA021110GA01HU | SETDB1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA619960ESR1HU | SETDB1 Antibody | Human, Rat | ELISA, WB, IHC |
SETDB1 Proteins
SETDB1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP021110MO CSB-EP021110MO CSB-BP021110MO CSB-MP021110MO CSB-EP021110MO-B |
Recombinant Mouse Histone-lysine N-methyltransferase SETDB1 (Setdb1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SETDB1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP619960HU CSB-BP619960HU CSB-MP619960HU CSB-EP619960HU-B |
Recombinant Human Histone-lysine N-methyltransferase SETDB1 (SETDB1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP619960HU | Recombinant Human Histone-lysine N-methyltransferase SETDB1 (SETDB1) | E.coli |
| CSB-EP619960HUe1 | Recombinant Human Histone-lysine N-methyltransferase SETDB1 (SETDB1) | E.coli |
SETDB1 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP764240XBE CSB-EP764240XBE CSB-BP764240XBE CSB-MP764240XBE CSB-EP764240XBE-B |
Recombinant Xenopus laevis Histone-lysine N-methyltransferase SETDB1 (setdb1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
