SCN11A
SCN11A，全稱為電壓門控鈉離子通道Nav1.9，也被稱為SCN11A蛋白。該蛋白主要在外周感覺神經元中表達，參與痛覺信號的傳遞。Nav1.9通道在痛覺感受器中呈現高表達，其功能是將疼痛信號從外周傳遞給中樞神經系統。研究發現，SCN11A基因的錯義突變會導致痛覺喪失，患者因此無法體驗疼痛感，無法避免經常性的組織損傷和嚴重致殘情況。Nav1.9通道突變在靜息電位時表現出超活性，引起傷害感受器的持續去極化、損害動作電位的產生和異常的突觸傳遞，從而引發痛覺缺失。此外，Nav1.9通道還與慢性疼痛密切相關，如神經病理性疼痛和炎癥性疼痛。針對Nav1.9通道的藥物研發已取得顯著進展，例如Vertex公司開發的VX-548，作為一種重構分子，在臨床階段取得令人興奮的進展，顯示出高效安全的鎮痛效果。
熱銷產品
SCN11A Antibody (CSB-PA883417LA01HU)
驗證數據
IHC image of CSB-PA883417LA01HU diluted at 1:500 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA883417LA01HU diluted at 1:500 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of HepG2 cells with CSB-PA883417LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
SCN11A Antibodies
SCN11A for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA961122 | SCN11A Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA591668 | SCN11A Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA924942 | SCN11A Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA883417LA01HU | SCN11A Antibody | Human | ELISA, IHC, IF |
| CSB-PA883417LB01HU | SCN11A Antibody, HRP conjugated | Human | ELISA |
| CSB-PA883417LC01HU | SCN11A Antibody, FITC conjugated | Human | |
| CSB-PA883417LD01HU | SCN11A Antibody, Biotin conjugated | Human | ELISA |
SCN11A Proteins
SCN11A Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP883417HU CSB-EP883417HU CSB-BP883417HU CSB-MP883417HU CSB-EP883417HU-B |
Recombinant Human Sodium channel protein type 11 subunit alpha (SCN11A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
