RUNX1
RUNX1，即Runt相關(guān)轉(zhuǎn)錄因子1，別名AML1、CBFA2、Runt-related transcription factor 1。它是一種由人類染色體21q22.3位置上的基因編碼的轉(zhuǎn)錄因子，屬于RUNX轉(zhuǎn)錄因子家族成員之一。RUNX1的作用機(jī)制涉及與DNA結(jié)合以及形成異源二聚體，其中RUNX1蛋白包含Runt同源結(jié)構(gòu)域（RHD），能夠介導(dǎo)與CBFβ構(gòu)成異源二聚體并促進(jìn)與DNA的結(jié)合，從而調(diào)控多種基因的表達(dá)。
RUNX1對(duì)于維持正常造血功能至關(guān)重要，它參與細(xì)胞分化、增殖、細(xì)胞周期、DNA修復(fù)、凋亡等多種生物學(xué)過程。RUNX1基因的突變可見于多種血液腫瘤，尤其在骨髓增生異常綜合征（MDS）和急性髓細(xì)胞白血病（AML）中發(fā)生頻率較高，并提示患者預(yù)后不良。RUNX1的異常表達(dá)或功能喪失與腫瘤發(fā)生發(fā)展有關(guān)，是髓系腫瘤研究中的關(guān)鍵分子之一。
熱銷產(chǎn)品
Recombinant Human Runt-related transcription factor 1 (Runx1) (CSB-EP020592HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗(yàn)證數(shù)據(jù)
Western blot analysis of extract from P19, Hela and 293 cells using AML1(RUNX1) Antibody
RUNX1 Antibodies
RUNX1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA020592GA01HU | RUNX1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA245126 | RUNX1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA570589 | Phospho-RUNX1 (Ser276) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA126379 | Phospho-RUNX1 (Ser303) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA110286 | Phospho-RUNX1 (Ser435) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA132524 | RUNX1 (Ab-435) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA070101 | Phospho-RUNX1 (S249) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA070102 | Phospho-RUNX1 (S435) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA070103 | Phospho-RUNX1 (S276) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA070104 | RUNX1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA070106 | RUNX1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA010571 | RUNX1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA161481 | RUNX1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA020592LA01HU | RUNX1 Antibody | Human | ELISA, WB, IF |
| CSB-PA020592LB01HU | RUNX1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA020592LC01HU | RUNX1 Antibody, FITC conjugated | Human | |
| CSB-PA020592LD01HU | RUNX1 Antibody, Biotin conjugated | Human | ELISA |
RUNX1 Proteins
RUNX1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP020592RA CSB-MP020592RA CSB-EP020592RA-B |
Recombinant Rat Runt-related transcription factor 1 (Runx1) | Yeast Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP020592RA | Recombinant Rat Runt-related transcription factor 1 (Runx1) | E.coli |
| CSB-BP020592RA | Recombinant Rat Runt-related transcription factor 1 (Runx1) | Baculovirus |
RUNX1 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP020592XBE CSB-EP020592XBE CSB-BP020592XBE CSB-MP020592XBE CSB-EP020592XBE-B |
Recombinant Xenopus laevis Runt-related transcription factor 1 (runx1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RUNX1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-EP020592HU | Recombinant Human Runt-related transcription factor 1 (Runx1) | E.coli |
