RORC

RORC，全稱為RAR related orphan receptor C，常見別名包括NR1F3、RORG、RZRG和TOR。該蛋白屬于核受體超家族中的ROR基因家族，參與晝夜節(jié)律、免疫調(diào)節(jié)、代謝和發(fā)育等過程。RORC蛋白在免疫細(xì)胞中發(fā)揮重要作用，特別是Th17細(xì)胞的分化和功能調(diào)控。研究發(fā)現(xiàn)，RORC蛋白的表達(dá)與自身免疫性疾病密切相關(guān)，如多發(fā)性硬化、銀屑病和類風(fēng)濕關(guān)節(jié)炎等。此外，RORC蛋白還參與淋巴器官發(fā)育和腸道免疫穩(wěn)態(tài)的維持。由于RORC蛋白在疾病發(fā)生發(fā)展中的作用，已成為研究的熱點，相關(guān)藥物研發(fā)也在進(jìn)行中，例如開發(fā)針對RORC蛋白的反向激動劑，以治療自身免疫性疾病。

熱銷產(chǎn)品

Recombinant Human Nuclear receptor ROR-gamma (RORC) (CSB-EP020071HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP020071HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) RORC.

RORC Antibody (CSB-PA020071LA01HU)

驗證數(shù)據(jù)

Western Blot
Positive WB detected in: HepG2 whole cell lysate
All lanes: RORC antibody at 5.2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 59, 56 kDa
Observed band size: 59 kDa

Western Blot
Positive WB detected in: HT29 whole cell lysate, MCF7 whole cell lysate, Jurkat whole cell lysate, HepG2 whole cell lysate
All lanes: RORC antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 59, 56 kDa
Observed band size: 59 kDa

IHC image of CSB-PA020071LA01HU diluted at 1:1000 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody

IHC image of CSB-PA020071LA01HU diluted at 1:1000 and staining in paraffin-embedded human skin tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody

IHC image of CSB-PA020071LA01HU diluted at 1:1000 and staining in paraffin-embedded mouse liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody

Human Nuclear receptor ROR-gamma(RORC) ELISA kit (CSB-EL020071HU)

驗證數(shù)據(jù)

貨號：CSB-EL020071HU

規(guī)格：96T/48T

靈敏度：3.12 pg/mL

檢測范圍：12.5 pg/mL-800 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

RORC Antibody

RORC Protein

RORC ELISA Kit

RORC Antibodies

RORC for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA020071GA01HU	RORC Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA020071LA01HU	RORC Antibody	Human	ELISA, WB, IHC
CSB-PA020071LB01HU	RORC Antibody, HRP conjugated	Human	ELISA
CSB-PA020071LC01HU	RORC Antibody, FITC conjugated	Human
CSB-PA020071LD01HU	RORC Antibody, Biotin conjugated	Human	ELISA
CSB-PA439853	RORC Antibody	Human,Mouse	ELISA,WB
CSB-PA004023	RORC Antibody	Human,Mouse	WB, ELISA

RORC Proteins

RORC Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP020071HU CSB-BP020071HU CSB-MP020071HU CSB-EP020071HU-B	Recombinant Human Nuclear receptor ROR-gamma (RORC)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP020071HU	Recombinant Human Nuclear receptor ROR-gamma (RORC)	E.coli

RORC Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP020071MO	Recombinant Mouse Nuclear receptor ROR-gamma (Rorc)	Yeast
CSB-EP020071MO CSB-BP020071MO CSB-MP020071MO CSB-EP020071MO-B	Recombinant Mouse Nuclear receptor ROR-gamma (Rorc)	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

RORC Proteins for Pongo abelii (Sumatran orangutan)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP729014PYX CSB-EP729014PYX CSB-BP729014PYX CSB-MP729014PYX CSB-EP729014PYX-B	Recombinant Pongo abelii Nuclear receptor ROR-gamma (RORC), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli