RICTOR
Rapamycin-insensitive companion of mTOR is a protein in humans that is encoded by RICTOR gene. Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
RICTOR Antibodies
RICTOR for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA761396ESR1HU | RICTOR Antibody | Human | ELISA, IHC |
| CSB-PA917257 | RICTOR Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA108659 | RICTOR Antibody | Human,Mouse | ELISA,IHC |
RICTOR Proteins
RICTOR Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP744164MO CSB-EP744164MO CSB-BP744164MO CSB-MP744164MO CSB-EP744164MO-B |
Recombinant Mouse Rapamycin-insensitive companion of mTOR (Rictor), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RICTOR Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP761396HU CSB-EP761396HU CSB-BP761396HU CSB-MP761396HU CSB-EP761396HU-B |
Recombinant Human Rapamycin-insensitive companion of mTOR (RICTOR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
