RGS9BP
RGS9BP，全稱為Regulator of G protein signaling 9 binding protein，常見別名有Rgs9bp。該蛋白主要在視網(wǎng)膜中表達(dá)，并定位于視桿外節(jié)膜。它通過與RGS9蛋白結(jié)合，穩(wěn)定其結(jié)構(gòu)并增強其在光感受器細(xì)胞和神經(jīng)元中的功能。RGS9BP與RGS9的相互作用對于視覺信號傳遞的速度和敏感性至關(guān)重要。在視網(wǎng)膜中，RGS9-RGS9BP復(fù)合物通過調(diào)控轉(zhuǎn)導(dǎo)素（G蛋白）的活性，影響光信號傳遞的速度和敏感性。在大腦中，該復(fù)合物參與多巴胺D2受體信號通路的調(diào)控，影響運動控制和獎賞機制。RGS9BP基因突變可能導(dǎo)致其與RGS9結(jié)合能力下降，進(jìn)而影響視覺信號處理或神經(jīng)遞質(zhì)調(diào)控。例如，某些突變與遲發(fā)性視網(wǎng)膜變性或運動障礙相關(guān)。RGS9BP過表達(dá)可能增強RGS9的穩(wěn)定性，導(dǎo)致GPCR信號過度抑制，影響光感受器細(xì)胞反應(yīng)或多巴胺信號傳遞；而表達(dá)降低可能導(dǎo)致RGS9降解增加，引起信號通路過度激活，與某些精神疾病或視網(wǎng)膜功能障礙相關(guān)。RGS9BP屬于RGS蛋白調(diào)控網(wǎng)絡(luò)的一部分，該網(wǎng)絡(luò)通過精細(xì)調(diào)控GPCR信號影響多種生理過程。
熱銷產(chǎn)品
RGS9BP Antibody (CSB-PA765076LA01HU)
驗證數(shù)據(jù)
Immunofluorescence staining of PC3 cells with CSB-PA765076LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
RGS9BP Antibodies
RGS9BP for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA765076LA01HU | RGS9BP Antibody | Human | ELISA, IF |
| CSB-PA765076LB01HU | RGS9BP Antibody, HRP conjugated | Human | ELISA |
| CSB-PA765076LC01HU | RGS9BP Antibody, FITC conjugated | Human | |
| CSB-PA765076LD01HU | RGS9BP Antibody, Biotin conjugated | Human | ELISA |
RGS9BP Proteins
RGS9BP Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP765076HU CSB-EP765076HU CSB-BP765076HU CSB-MP765076HU CSB-EP765076HU-B |
Recombinant Human Regulator of G-protein signaling 9-binding protein (RGS9BP), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
