RFWD2
E3 ubiquitin-protein ligase RFWD2 is a protein in humans that is encoded by RFWD2 gene. E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes.
RFWD2 Antibodies
RFWD2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA019607GA01HU | RFWD2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA050025 | Phospho-RFWD2 (S387) Antibody | Human,Mouse | WB, ELISA |
| CSB-PA050026 | RFWD2 Antibody | Human,Mouse | WB, ELISA |
| CSB-PA050027 | RFWD2 Antibody | Human,Mouse | WB, ELISA |
RFWD2 Proteins
RFWD2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP822821HU CSB-BP822821HU CSB-EP822821HU-B |
Recombinant Human E3 ubiquitin-protein ligase COP1 (COP1) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP822821HU | Recombinant Human E3 ubiquitin-protein ligase COP1 (COP1) | E.coli |
RFWD2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP886432MO CSB-EP886432MO CSB-BP886432MO CSB-MP886432MO CSB-EP886432MO-B |
Recombinant Mouse E3 ubiquitin-protein ligase RFWD2 (Rfwd2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RFWD2 Proteins for Homo sapiens(Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-CF822821HU | Recombinant Human E3 ubiquitin-protein ligase COP1 (COP1) | in vitro E.coli expression system |
