QSOX1

QSOX1，全稱為Quiescin Sulfhydryl Oxidase 1，常見別名包括thiol oxidase 1。該蛋白在多種組織中廣泛表達，尤其在胰腺、乳腺和免疫細胞等分泌旺盛的細胞中活性較高。QSOX1參與蛋白質的正確折疊，幫助新生蛋白質形成正確的二硫鍵結構，維持蛋白質的穩定性和功能。此外，QSOX1還涉及細胞外基質的重塑、細胞遷移和粘附等過程。
QSOX1的異常表達與多種疾病相關，包括癌癥、神經退行性疾病和纖維化疾病。在腫瘤中，QSOX1常出現過表達，促進腫瘤細胞的侵襲和轉移。QSOX1的表達水平異常也與某些癌癥的耐藥性相關。相反，QSOX1表達降低可能導致蛋白質折疊異常，引發內質網應激，甚至細胞凋亡。QSOX1的突變可能影響其酶活性，導致二硫鍵形成障礙，進而影響依賴其功能的蛋白質的穩定性。QSOX1在維持蛋白質穩態和細胞功能中起關鍵作用，其表達水平的異常與多種病理過程密切相關，使其成為潛在的疾病治療靶點。目前，針對QSOX1的藥物研發正在積極進行中，以期找到治療癌癥、神經退行性疾病等疾病的新方法。

熱銷產品

Recombinant Human Sulfhydryl oxidase 1 (QSOX1), partial (CSB-EP019144HU1)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

QSOX1 Antibody (CSB-PA019144LA01HU)

驗證數據

Western Blot
Positive WB detected in: Hela whole cell lysate, Rat heart tissue
All lanes: QSOX1 antibody at 5.6μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 83 kDa
Observed band size: 83 kDa

IHC image of CSB-PA019144LA01HU diluted at 1:400 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA019144LA01HU diluted at 1:400 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human Sulfhydryl oxidase 1(QSOX1) ELISA kit (CSB-EL019144HU)

驗證數據

貨號：CSB-EL019144HU

規格：96T/48T

靈敏度：3.9 pg/mL

檢測范圍：15.6 pg/mL-1000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

QSOX1 Antibody

QSOX1 Protein

QSOX1 ELISA Kit

QSOX1 Antibodies

QSOX1 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA019144GA01HU	QSOX1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA019144LA01HU	QSOX1 Antibody	Human, Rat	ELISA, WB, IHC
CSB-PA019144LB01HU	QSOX1 Antibody, HRP conjugated	Human	ELISA
CSB-PA019144LC01HU	QSOX1 Antibody, FITC conjugated	Human
CSB-PA019144LD01HU	QSOX1 Antibody, Biotin conjugated	Human	ELISA

QSOX1 Proteins

QSOX1 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP019144HU1 CSB-BP019144HU1 CSB-MP019144HU1 CSB-EP019144HU1-B	Recombinant Human Sulfhydryl oxidase 1 (QSOX1), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF019144HU	Recombinant Human Sulfhydryl oxidase 1 (QSOX1)	in vitro E.coli expression system
CSB-EP019144HU1	Recombinant Human Sulfhydryl oxidase 1 (QSOX1), partial	E.coli