PRKACA
PRKACA，cAMP-dependent protein kinase catalytic subunit alpha,別名PKCA1、Cs-PKA等。PRKACA是蛋白激酶A（PKA）的α催化亞基，PKA是一種由cAMP激活的絲氨酸/蘇氨酸蛋白激酶，由兩個(gè)催化亞基和兩個(gè)調(diào)節(jié)亞基組成。在沒(méi)有cAMP時(shí)，PKA以鈍化復(fù)合體形式存在。cAMP與調(diào)節(jié)亞基結(jié)合后，導(dǎo)致調(diào)節(jié)亞基構(gòu)象變化，使調(diào)節(jié)亞基和催化亞基解離，釋放出催化亞基，進(jìn)而使細(xì)胞內(nèi)某些蛋白的絲氨酸或蘇氨酸殘基磷酸化，改變這些蛋白的活性，影響相關(guān)基因的表達(dá)。PRKACA參與調(diào)節(jié)多種細(xì)胞功能，包括糖原、糖和脂質(zhì)的代謝，以及晝夜睡眠/覺(jué)醒周期、快速眼動(dòng)睡眠等生理過(guò)程。PRKACA的異常活性與多種疾病相關(guān)，如腎上腺皮質(zhì)腺瘤、充血性心力衰竭和原發(fā)性色素性結(jié)節(jié)性腎上腺皮質(zhì)疾病。
熱銷(xiāo)產(chǎn)品
Recombinant Human cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) (CSB-EP018688HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PRKACA Antibody (CSB-PA018688LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, A549 whole cell lysate
All lanes: PRKACA antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 41, 40 kDa
Observed band size: 41 kDa
IHC image of CSB-PA018688LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA018688LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
PRKACA Antibodies
PRKACA for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA018688GA01HU | PRKACA Antibody | Human | ELISA,WB |
| CSB-PA157769 | Phospho-PRKACA (Thr197) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA235804 | PRKACA Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA030210 | Phospho-PRKACA (S338) Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA018688LA01HU | PRKACA Antibody | Human | ELISA, WB, IHC |
| CSB-PA018688LB01HU | PRKACA Antibody, HRP conjugated | Human | ELISA |
| CSB-PA018688LC01HU | PRKACA Antibody, FITC conjugated | Human | |
| CSB-PA018688LD01HU | PRKACA Antibody, Biotin conjugated | Human | ELISA |
PRKACA Proteins
PRKACA Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP018688HU CSB-BP018688HU CSB-MP018688HU CSB-EP018688HU-B |
Recombinant Human cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP018688HU | Recombinant Human cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) | E.coli |
| CSB-EP018688HUe2 | Recombinant Human cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) | E.coli |
PRKACA Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP018688RA CSB-EP018688RA CSB-BP018688RA CSB-MP018688RA CSB-EP018688RA-B |
Recombinant Rat cAMP-dependent protein kinase catalytic subunit alpha (Prkaca) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PRKACA Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP018688PI CSB-EP018688PI CSB-BP018688PI CSB-MP018688PI CSB-EP018688PI-B |
Recombinant Pig cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PRKACA Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP018688MO CSB-EP018688MO CSB-BP018688MO CSB-MP018688MO CSB-EP018688MO-B |
Recombinant Mouse cAMP-dependent protein kinase catalytic subunit alpha (Prkaca) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PRKACA Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP018688BO CSB-EP018688BO CSB-BP018688BO CSB-MP018688BO CSB-EP018688BO-B |
Recombinant Bovine cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PRKACA Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP018688DXU CSB-EP018688DXU CSB-BP018688DXU CSB-MP018688DXU CSB-EP018688DXU-B |
Recombinant Cricetulus griseus cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PRKACA Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP822648DO CSB-BP822648DO CSB-MP822648DO CSB-EP822648DO-B |
Recombinant Dog cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PRKACA Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP865034SH CSB-EP865034SH CSB-BP865034SH CSB-MP865034SH CSB-EP865034SH-B |
Recombinant Sheep cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PRKACA Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-EP822648DO | Recombinant Dog cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) | E.coli |
