POU5F1
POU5F1 is also known as Oct3, Oct4, Otf3 or NF-A3. It is encoded by the POU5F1 gene, which belongs to POU transcription factor family, class-5 subfamily.
POU5F1 gene and located on the human chromosome 6p21.3. It has multiple transcription initiation sites, leading to a diversity of POU5F1 proteins. There are four protein subtypes (Oct4A, oct4b-190, oct4b-265 and oct4b-164).
Oct4 is mainly expressed in embryonic stem cells, embryonic germ cells and embryonic/germ cell tumors, but is less expressed in adult tissues. In embryonic germ cells, Oct4 expression is down-regulated as cells differentiate.
Oct4 consists of three domains: N-transcription domain, POU binding domain and C-transcription domain. POU binding domain is a conserved DNA binding domain that binds to DNA containing an octamer motif to regulate transcription of downstream target genes.
Oct4 participates in the regulation of several signaling pathways, including transforming growth factor (TGF) beta pathway, fibroblast growth factor (FGF) pathway, phosatidylinositol-3-kinase (PI3K) pathway, Wnt pathway, etc.
POU5F1 regulates the expression of target genes by combining with octamer motif (5'-ATTTGCAT-3') in promoter or enhancer regions
POU5F1 is critical for early embryogenesis and for embryonic stem cell pluripotency. In addition, POU5F1 may be involved in the occurrence and development of malignant tumors.
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CSB-MA018403A0m (Oct4 Monoclonal Antibody) is a product of CUSABIO. The product can be used in human, rat and mouse. It has been validated in various applications, including ELISA, WB, IHC, IF and FC.
POU5F1 Antibodies
POU5F1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA018403GA01HU | POU5F1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA11579D0Rb | POU5F1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA11579C0Rb | POU5F1 Antibody, FITC conjugated | Human | |
| CSB-PA11579B0Rb | POU5F1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA11579A0Rb | POU5F1 Antibody | Human | ELISA, WB, IHC |
| CSB-PA694841 | POU5F1 Antibody | Human | ELISA,WB |
| CSB-PA003509 | POU5F1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA550936 | POU5F1 Antibody | Human | ELISA,WB,IHC |
| CSB-MA018403A0m | OCT4 Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, IHC, IF, FC |
POU5F1 Proteins
POU5F1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018403MO CSB-EP018403MO CSB-BP018403MO CSB-MP018403MO CSB-EP018403MO-B |
Recombinant Mouse POU domain, class 5, transcription factor 1 (Pou5f1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
POU5F1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018403BO CSB-EP018403BO CSB-BP018403BO CSB-MP018403BO CSB-EP018403BO-B |
Recombinant Bovine POU domain, class 5, transcription factor 1 (POU5F1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
POU5F1 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP716372MOW CSB-EP716372MOW CSB-BP716372MOW CSB-MP716372MOW CSB-EP716372MOW-B |
Recombinant Macaca mulatta POU domain, class 5, transcription factor 1 (POU5F1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
POU5F1 Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP770321EQV CSB-EP770321EQV CSB-BP770321EQV CSB-MP770321EQV CSB-EP770321EQV-B |
Recombinant Pan troglodytes POU domain, class 5, transcription factor 1 (POU5F1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
POU5F1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP845853DIL CSB-EP845853DIL CSB-BP845853DIL CSB-MP845853DIL CSB-EP845853DIL-B |
Recombinant Danio rerio POU domain, class 5, transcription factor 1 (pou5f1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
POU5F1 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP879986PI CSB-EP879986PI CSB-BP879986PI CSB-MP879986PI CSB-EP879986PI-B |
Recombinant Pig POU domain, class 5, transcription factor 1 (POU5F1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
POU5F1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP018403HU CSB-MP018403HU CSB-EP018403HU-B |
Recombinant Human POU domain, class 5, transcription factor 1 (POU5F1) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP018403HU | Recombinant Human POU domain, class 5, transcription factor 1 (POU5F1) | E.coli |
