POSTN
POSTN，全稱為Periostin，別名OSF2、PDLPOSTN、PN，是一種細胞外基質分泌蛋白，在心肌梗死后的組織發育和再生中發揮重要作用，涉及傷口愈合和心室重構。該蛋白與整合素和BMP1結合，支持細胞粘附、細胞遷移，與多種生理和病理過程相關。POSTN在骨關節炎的軟骨細胞中高度表達，促進細胞外基質的降解和上調炎癥因子，加速疾病進展。此外，POSTN還與腫瘤的遷移、增殖和血管生成能力有關，在多種腫瘤組織中表達上調。在藥物研發方面，針對POSTN的藥物正在開發中，旨在通過抑制POSTN的表達或活性，治療心血管疾病、骨關節炎和腫瘤等疾病。一些研究顯示，抑制POSTN可以減少心臟瓣膜疾病、骨骼和牙齒缺陷的發生。目前，POSTN已成為藥物研發的一個重要靶點，相關藥物正處于臨床研究階段。
熱銷產品
POSTN Recombinant Monoclonal Antibody (CSB-RA119753A0HU)
驗證數據
IHC image of CSB-RA119753A0HU diluted at 1:50 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.31% DAB.
Overlay Peak curve showing 293T cells stained with CSB-RA119753A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
Human periostin/osteoblast specific factor 2 (POSTN) ELISA kit (CSB-E16444h)
驗證數據
貨號：CSB-E16444h
規格：96T/48T
靈敏度：1.56 ng/mL
檢測范圍：6.25 ng/mL-400 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
POSTN Antibodies
POSTN for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA09905C0Rb | POSTN Antibody, FITC conjugated | Human | |
| CSB-PA09905A0Rb | POSTN Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA018381GA01HU | POSTN Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA619962ESR2HU | POSTN Antibody | Human | ELISA, IHC |
| CSB-RA119753A0HU | POSTN Recombinant Monoclonal Antibody | Human | ELISA, IHC, FC |
| CSB-RA619962MA1HU | POSTN Recombinant Monoclonal Antibody | Human | ELISA, IF, FC |
POSTN ELISA Kit
POSTN ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E16444h | Human periostin/osteoblast specific factor 2 (POSTN) ELISA kit | serum, plasma, tissue homogenates | 1.56 ng/mL |
