PMS2
Mismatch repair endonuclease PMS2 is a protein in humans that is encoded by PMS2 gene. Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected.
PMS2 Antibodies
PMS2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA018246GA01HU | PMS2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA003827 | PMS2 Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA808697 | PMS2 Antibody | Human | ELISA,IHC |
| CSB-PA782127 | PMS2 Antibody | Human | ELISA,IHC |
| CSB-PA786759 | PMS2 Antibody | Human | ELISA,WB,IHC |
PMS2 Proteins
PMS2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP018246HU CSB-EP018246HU CSB-BP018246HU CSB-MP018246HU CSB-EP018246HU-B |
Recombinant Human Mismatch repair endonuclease PMS2 (PMS2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PMS2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP018246MO CSB-EP018246MO CSB-BP018246MO CSB-MP018246MO CSB-EP018246MO-B |
Recombinant Mouse Mismatch repair endonuclease PMS2 (Pms2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
