PLK4
Serine/threonine-protein kinase PLK4 is a protein in humans that is encoded by PLK4 gene. Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors.
PLK4 Antibodies
PLK4 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA018196GA01HU | PLK4 Antibody | Human | ELISA, IHC. IF |
| CSB-PA018196XA01phHU | Phospho-PLK4 (S305) Antibody | Homo sapiens (Human) | ELISA |
PLK4 Proteins
PLK4 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP018196BO CSB-EP018196BO CSB-BP018196BO CSB-MP018196BO CSB-EP018196BO-B |
Recombinant Bovine Serine/threonine-protein kinase PLK4 (PLK4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PLK4 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP018196RA CSB-EP018196RA CSB-BP018196RA CSB-MP018196RA CSB-EP018196RA-B |
Recombinant Rat Serine/threonine-protein kinase PLK4 (Plk4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PLK4 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP018196HU CSB-EP018196HU CSB-BP018196HU CSB-MP018196HU CSB-EP018196HU-B |
Recombinant Human Serine/threonine-protein kinase PLK4 (PLK4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PLK4 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP018196XBF CSB-EP018196XBF CSB-BP018196XBF CSB-MP018196XBF CSB-EP018196XBF-B |
Recombinant Xenopus tropicalis Serine/threonine-protein kinase PLK4 (plk4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PLK4 Proteins for Pongo abelii (Sumatran orangutan)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP722367PYX CSB-EP722367PYX CSB-BP722367PYX CSB-MP722367PYX CSB-EP722367PYX-B |
Recombinant Pongo abelii Serine/threonine-protein kinase PLK4 (PLK4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PLK4 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP731078MO CSB-EP731078MO CSB-BP731078MO CSB-MP731078MO CSB-EP731078MO-B |
Recombinant Mouse Serine/threonine-protein kinase PLK4 (Plk4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PLK4 Proteins for Xenopus laevis (African clawed frog)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP747447XBE CSB-EP747447XBE CSB-BP747447XBE CSB-MP747447XBE CSB-EP747447XBE-B |
Recombinant Xenopus laevis Serine/threonine-protein kinase PLK4 (plk4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PLK4 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP773631DIL CSB-EP773631DIL CSB-BP773631DIL CSB-MP773631DIL CSB-EP773631DIL-B |
Recombinant Danio rerio Serine/threonine-protein kinase PLK4 (plk4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
