PHB2
PHB2，全稱為Prohibitin-2，也被稱為BAP、REA、p22、hBAP、Bap37、BCAP37、PNAS-141等。該蛋白在細(xì)胞膜、線粒體內(nèi)膜、細(xì)胞核中均有分布，參與細(xì)胞增殖、分化、衰老、凋亡等多種生物學(xué)進(jìn)程。PHB2蛋白與PHB蛋白形成大型環(huán)狀復(fù)合物，穩(wěn)定線粒體呼吸酶，維持線粒體完整性，對線粒體形態(tài)發(fā)生、神經(jīng)元存活和正常壽命至關(guān)重要。此外，PHB2蛋白還參與調(diào)控細(xì)胞因子和性激素的轉(zhuǎn)錄，以及IGFBP6誘導(dǎo)的細(xì)胞遷移。研究表明，PHB2蛋白在平滑肌細(xì)胞中表達(dá)，能夠抑制血管損傷后新生內(nèi)膜的形成。PHB2蛋白通過與hnRNPA1的RGG-box結(jié)構(gòu)域結(jié)合，抑制hnRNPA1對pre-pkm mRNA的剪切，從而維持血管平滑肌細(xì)胞收縮表型。此外，PHB2蛋白還參與調(diào)控線粒體自噬，通過與PINK1-PRKN/Parkin依賴性的線粒體自噬途徑相互作用，促進(jìn)腫瘤細(xì)胞的生存。目前，針對PHB2蛋白的藥物研發(fā)尚處于探索階段，但其在疾病中的作用機(jī)制為相關(guān)疾病的治療提供了新的思路和靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Prohibitin-2 (PHB2) (CSB-EP859937HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PHB2 Antibody (CSB-PA859937ESR2HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: PHB2 antibody at 3μg/ml
Lane 1: Hela whole cell lysate
Lane 2: K562 whole cell lysate
Lane 3: MCF-7 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 34, 30 kDa
Observed band size: 34 kDa
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA859937ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA859937ESR2HU at dilution of 1:100
PHB2 Antibodies
PHB2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA017886GA01HU | PHB2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA859937ESR2HU | PHB2 Antibody | Human | ELISA, WB, IHC |
PHB2 Proteins
PHB2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP859937HU CSB-BP859937HU CSB-MP859937HU CSB-EP859937HU-B |
Recombinant Human Prohibitin-2 (PHB2) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP859937HU | Recombinant Human Prohibitin-2 (PHB2) | E.coli |
