PDGFB
血小板衍生生長因子β鏈（PDGF-B）是一種由血小板分泌的關(guān)鍵調(diào)控蛋白，也被稱為PDGF-BB。它在人體中通過與特定受體結(jié)合，參與調(diào)控細(xì)胞增殖、血管新生及組織修復(fù)過程，對胚胎發(fā)育和創(chuàng)傷愈合具有重要作用。該蛋白常與α鏈形成異源二聚體，通過激活細(xì)胞表面受體引發(fā)級聯(lián)反應(yīng)，影響平滑肌細(xì)胞遷移、成纖維細(xì)胞活化等生理行為。
異常表達(dá)的PDGF-B與多種病理狀態(tài)相關(guān)，包括實(shí)體瘤的生長及轉(zhuǎn)移、肺纖維化、硬皮病等纖維化疾病，以及動(dòng)脈粥樣硬化等心血管病變。在腫瘤微環(huán)境中，其過度分泌可促進(jìn)血管異常增生，為癌細(xì)胞提供養(yǎng)分支持。針對PDGF-B的靶向干預(yù)成為研究熱點(diǎn)：單克隆抗體及小分子抑制劑已在臨床試驗(yàn)中展現(xiàn)潛力，例如抗血管生成藥物伊馬替尼可通過阻斷相關(guān)通路抑制腫瘤進(jìn)展；新型融合蛋白藥物則嘗試通過中和PDGF-B活性緩解纖維化進(jìn)程。目前多個(gè)候選藥物處于臨床評估階段，為相關(guān)疾病的治療提供了新方向。
熱銷產(chǎn)品
Recombinant Human Platelet-derived growth factor subunit B (PDGFB) (CSB-EP017709HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PDGFB Antibody (CSB-PA017709KA01HU)
驗(yàn)證數(shù)據(jù)
Western blot analysis of extracts of A431 cell lines using PDGFB antibody.
PDGFB Antibodies
PDGFB for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA017709KA01HU | PDGFB Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA153276 | PDGFB Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA020300 | PDGFB Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA911363 | PDGFB Antibody | Human,Mouse,Rat | ELISA,IHC |
PDGFB Proteins
PDGFB Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017709CA CSB-EP017709CA CSB-BP017709CA CSB-MP017709CA CSB-EP017709CA-B |
Recombinant Cat Platelet-derived growth factor subunit B (PDGFB) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDGFB Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017709PI CSB-EP017709PI CSB-BP017709PI CSB-MP017709PI CSB-EP017709PI-B |
Recombinant Pig Platelet-derived growth factor subunit B (PDGFB) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDGFB Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017709MO CSB-BP017709MO CSB-MP017709MO CSB-EP017709MO-B |
Recombinant Mouse Platelet-derived growth factor subunit B (Pdgfb) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP004141MO | Recombinant Mouse Platelet-derived growth factor subunit B (Pdgfb) (Active) | E.coli |
PDGFB Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP017709HU CSB-MP017709HU CSB-EP017709HU-B |
Recombinant Human Platelet-derived growth factor subunit B (PDGFB) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP002631HU | Recombinant Human Platelet-derived growth factor subunit B protein (PDGFB) | E.Coli |
| CSB-EP017709HU | Recombinant Human Platelet-derived growth factor subunit B (PDGFB) | E.coli |
| CSB-EP017709HUc7 | Recombinant Human Platelet-derived growth factor subunit B (PDGFB) | E.coli |
| CSB-AP003821HU | Recombinant Human Platelet-derived growth factor subunit B (PDGFB) (Active) | E.coli |
| CSB-AP005941HU | Recombinant Human Platelet-derived Growth Factor-BB (PDGFB), partial (Active) (GMP) | E.Coli |
| CSB-YP017709HU-WD | Recombinant Human Platelet-derived growth factor subunit B (PDGFB) (Active) | Yeast |
PDGFB Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP754297DO CSB-EP754297DO CSB-BP754297DO CSB-MP754297DO CSB-EP754297DO-B |
Recombinant Dog Platelet-derived growth factor subunit B (PDGFB) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDGFB Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP850135SH CSB-BP850135SH CSB-MP850135SH CSB-EP850135SH-B |
Recombinant Sheep Platelet-derived growth factor subunit B (PDGFB) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
