PADI2
PADI2，即肽基精氨酸脫亞胺酶2，別名PAD2、PDI2、PAD-H19。它是一種由人類基因編碼的鈣依賴性酶，主要在多種組織中表達，尤其在結腸、大腦和其他組織中表達量較高。PADI2的作用機制是通過催化蛋白質的翻譯后脫亞胺化，將精氨酸殘基轉化為瓜氨酸，這一過程在鈣離子存在下進行。PADI2在神經退行性疾病（如阿爾茨海默病和多發性硬化癥）的發病和進展中發揮作用，并且與青光眼的發病機制有關。PADI2還與多種腫瘤的遺傳易感性相關，包括乳腺癌，是癌癥生物標志物和潛在的治療靶點。
熱銷產品
Recombinant Human Protein-arginine deiminase type-2 (PADI2) (CSB-MP896493HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PADI2 Antibody (CSB-PA896493YA01HU)
驗證數據
Western Blot
Positive WB detected in: K562 whole cell lysate
All lanes: PADI2 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 76, 50 kDa
Observed band size: 76, 50 kDa
IHC image of CSB-PA896493YA01HU diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of Hela cells with CSB-PA896493YA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
PADI2 Antibodies
PADI2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA017377GA01HU | PADI2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA896493YA01HU | PADI2 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA896493YD01HU | PADI2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA896493LA01HU | PADI2 Antibody | Human, Mouse | ELISA, WB |
| CSB-PA896493LD01HU | PADI2 Antibody, Biotin conjugated | Human | ELISA |
PADI2 Proteins
PADI2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP896493HU | Recombinant Human Protein-arginine deiminase type-2 (PADI2) | Yeast |
| CSB-EP896493HU | Recombinant Human Protein-arginine deiminase type-2 (PADI2) | E.coli |
| CSB-BP896493HU CSB-EP896493HU-B |
Recombinant Human Protein-arginine deiminase type-2 (PADI2) | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP896493HU | Recombinant Human Protein-arginine deiminase type-2 (PADI2) | Mammalian cell |
| CSB-MP896493HUd7 | Recombinant Human Protein-arginine deiminase type-2 (PADI2) | Mammalian cell |
| CSB-MP896493HUd7 | Recombinant Human Protein-arginine deiminase type-2 (PADI2) | Mammalian cell |
