NUP98

NUP98，即核孔蛋白98，別名ADAR2、ANUP96、Nup98。NUP98是核孔復合體（NPC）的重要組成部分，主要存在于NPC的胞質區及核質區內。NUP98在NPC的組裝和/或維護中發揮作用，Nup98和Nup96參與雙向跨NPC的運輸。NUP98對RNA從細胞核向細胞質的運輸調控作用，其N末端的FG重復結構域是跨核運輸的大分子在NPC上的錨定位點，而C末端含有RNA的結合序列，參與RNA核漿運輸。NUP98的異常表達或融合基因的形成與多種髓系腫瘤的發生發展相關，其通過染色體易位等方式形成融合基因，在多種信號分子的相互作用下，調控下游轉錄因子表達，從而干擾細胞的有絲分裂、基因轉錄及核漿運輸等過程。

熱銷產品

Recombinant Human Nuclear pore complex protein Nup98-Nup96 (NUP98), partial (CSB-MP016209HU)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NUP98 Recombinant Monoclonal Antibody (CSB-RA995655A0HU)

驗證數據

Western Blot
Positive WB detected in: K562 whole cell lysate, Hela whole cell lysate
All lanes: NUP98 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 198, 188, 98, 97, 196, 187 kDa
Observed band size: 100 kDa

IHC image of CSB-RA995655A0HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Immunofluorescence staining of Hela Cells with CSB-RA995655A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

NUP98 Antibody

NUP98 Protein

NUP98 Antibodies

NUP98 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA282096	NUP98 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA140909	NUP98 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA016209LA01HU	NUP98 Antibody	Human	ELISA, WB, IF, IP
CSB-PA016209LB01HU	NUP98 Antibody, HRP conjugated	Human	ELISA
CSB-PA016209LC01HU	NUP98 Antibody, FITC conjugated	Human
CSB-PA016209LD01HU	NUP98 Antibody, Biotin conjugated	Human	ELISA
CSB-RA995655A0HU	NUP98 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IF

NUP98 Proteins

NUP98 Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP016209RA CSB-EP016209RA CSB-BP016209RA CSB-MP016209RA CSB-EP016209RA-B	Recombinant Rat Nuclear pore complex protein Nup98-Nup96 (Nup98), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NUP98 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP016209HU CSB-EP016209HU CSB-BP016209HU CSB-EP016209HU-B	Recombinant Human Nuclear pore complex protein Nup98-Nup96 (NUP98), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-MP016209HU	Recombinant Human Nuclear pore complex protein Nup98-Nup96 (NUP98), partial	Mammalian cell

NUP98 Proteins for Dictyostelium discoideum (Slime mold)

產品貨號	產品名稱	來源
CSB-YP690541DKK CSB-EP690541DKK CSB-BP690541DKK CSB-MP690541DKK CSB-EP690541DKK-B	Recombinant Dictyostelium discoideum Nuclear pore complex protein Nup98-Nup96 (nup98), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli