NPTX1
神經(jīng)元五肽重復(fù)蛋白1（NPTX1），又稱NP1或NPTX1，是長五肽重復(fù)蛋白家族成員，在大腦皮質(zhì)、海馬及小腦中高度表達。這種分泌型糖蛋白通過結(jié)合AMPA受體亞基GluA4，調(diào)控突觸可塑性和神經(jīng)遞質(zhì)釋放，維持神經(jīng)網(wǎng)絡(luò)興奮性平衡。在生理狀態(tài)下，NPTX1參與記憶形成和神經(jīng)元保護，其結(jié)構(gòu)中的鈣結(jié)合域使其能響應(yīng)細胞外鈣離子濃度變化，動態(tài)調(diào)節(jié)突觸后信號傳導(dǎo)。
NPTX1異常表達與多種神經(jīng)系統(tǒng)疾病密切相關(guān)。阿爾茨海默病患者腦內(nèi)Aβ斑塊周圍常檢測到NPTX1聚集，其通過激活補體系統(tǒng)加劇小膠質(zhì)細胞炎癥反應(yīng)，導(dǎo)致神經(jīng)元丟失。帕金森病模型顯示，NPTX1水平升高會抑制多巴胺能神經(jīng)元活性，加速運動功能障礙。近期研究還發(fā)現(xiàn)，NPTX1在胰腺癌轉(zhuǎn)移中發(fā)揮關(guān)鍵作用——它與細胞膜受體AMIGO2結(jié)合后，通過穩(wěn)定HIF1α蛋白促進腫瘤細胞在缺氧環(huán)境下的侵襲能力，這一機制在肝轉(zhuǎn)移病灶中尤為顯著。針對該通路的單克隆抗體h31B01已進入臨床試驗階段，在動物模型中可抑制60%以上的肝轉(zhuǎn)移灶形成，為胰腺癌治療提供了新策略。目前基于NPTX1的血液檢測技術(shù)正用于神經(jīng)退行性疾病的早期篩查，其重組蛋白產(chǎn)品也在神經(jīng)修復(fù)研究中展現(xiàn)潛力。
熱銷產(chǎn)品
Recombinant Human Neuronal pentraxin-1 (NPTX1), partial (CSB-EP614901HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
NPTX1 Antibody (CSB-PA614901LA01HU)
驗證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA614901LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA614901LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human Neuronal Pentraxin-1(NPTX-1) ELISA kit (CSB-E14336h)
驗證數(shù)據(jù)
貨號：CSB-E14336h
規(guī)格：96T/48T
靈敏度：1.95 pg/mL
檢測范圍：7.8 pg/mL-500 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
NPTX1 Antibodies
NPTX1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA016029GA01HU | NPTX1 Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA169583 | NPTX1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA181075 | NPTX1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA614901LA01HU | NPTX1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA614901LB01HU | NPTX1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA614901LC01HU | NPTX1 Antibody, FITC conjugated | Human | |
| CSB-PA614901LD01HU | NPTX1 Antibody, Biotin conjugated | Human | ELISA |
NPTX1 Proteins
NPTX1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP016029RA CSB-EP016029RA CSB-BP016029RA CSB-MP016029RA CSB-EP016029RA-B |
Recombinant Rat Neuronal pentraxin-1 (Nptx1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NPTX1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP614901HU CSB-BP614901HU CSB-MP614901HU CSB-EP614901HU-B |
Recombinant Human Neuronal pentraxin-1 (NPTX1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP614901HU | Recombinant Human Neuronal pentraxin-1 (NPTX1), partial | E.coli |
NPTX1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP714021MO CSB-BP714021MO CSB-EP714021MO-B |
Recombinant Mouse Neuronal pentraxin-1 (Nptx1) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
NPTX1 ELISA Kit
NPTX1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E14336h | Human Neuronal Pentraxin-1(NPTX-1) ELISA kit | serum, plasma | 1.95 pg/mL |
