NLRP1
NACHT, LRR and PYD domains-containing protein 1 is a protein in humans that is encoded by NLRP1 gene. As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death.
NLRP1 Antibodies
NLRP1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA015864GA01HU | NLRP1 Antibody | Human | ELISA,IHC |
| CSB-PA871630EA01HU | NLRP1 Antibody | Human | ELISA, IF |
| CSB-PA871630EB01HU | NLRP1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA871630EC01HU | NLRP1 Antibody, FITC conjugated | Human | |
| CSB-PA871630ED01HU | NLRP1 Antibody, Biotin conjugated | Human | ELISA |
NLRP1 ELISA Kit
NLRP1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL015864HU | Human NACHT, LRR and PYD domains-containing protein 1(NLRP1) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 4.67 pg/mL |
