NLK
Serine/threonine-protein kinase NLK is a protein in humans that is encoded by NLK gene. Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway.
NLK Antibodies
NLK for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA890657ESR1HU | NLK Antibody | Human | ELISA, IHC |
| CSB-PA890657ESR2HU | NLK Antibody | Human | ELISA, WB, IHC |
NLK Proteins
NLK Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015859MO CSB-EP015859MO CSB-BP015859MO CSB-MP015859MO CSB-EP015859MO-B |
Recombinant Mouse Serine/threonine-protein kinase NLK (Nlk) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NLK Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015859RA CSB-EP015859RA CSB-BP015859RA CSB-MP015859RA CSB-EP015859RA-B |
Recombinant Rat Serine/threonine-protein kinase NLK (Nlk) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NLK Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015859DO CSB-EP015859DO CSB-BP015859DO CSB-MP015859DO CSB-EP015859DO-B |
Recombinant Dog Serine/threonine-protein kinase NLK (NLK), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NLK Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015859BO CSB-EP015859BO CSB-BP015859BO CSB-MP015859BO CSB-EP015859BO-B |
Recombinant Bovine Serine/threonine-protein kinase NLK (NLK), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NLK Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP890657HU CSB-BP890657HU CSB-MP890657HU CSB-EP890657HU-B |
Recombinant Human Serine/threonine-protein kinase NLK (NLK) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP890657HU | Recombinant Human Serine/threonine-protein kinase NLK (NLK) | E.coli |
